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    Ak1 adenylate kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24183, updated on 13-Aug-2019

    Summary

    Official Symbol
    Ak1provided by RGD
    Official Full Name
    adenylate kinase 1provided by RGD
    Primary source
    RGD:2076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ak 1
    Summary
    catalyzes the conversion of ATP and AMP to ADP in adenine nucleotide metabolism [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Muscle (RPKM 1320.1), Heart (RPKM 466.8) and 5 other tissues See more

    Genomic context

    See Ak1 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11652143..11659135)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (16995977..17002969)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene adenylate kinase isoenzyme 1-like Neighboring gene endoglin Neighboring gene folylpolyglutamate synthase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    • Homologs of the Ak1 gene: The Ak1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and frog.
    • Orthologs

    Clone Names

    • MGC108678

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoside diphosphate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to phosphotransferase activity, phosphate group as acceptor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    ADP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    AMP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    adenine metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cerebellum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    inosine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    muscle organ development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    neuron differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    nucleoside diphosphate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoside diphosphate phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside triphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoside triphosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    olfactory bulb development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of glucose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron maturation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to testosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    outer dense fiber ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    sarcomere IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    adenylate kinase isoenzyme 1
    Names
    ATP-AMP transphosphorylase 1
    ATP:AMP phosphotransferase
    adenylate monophosphate kinase
    myokinase
    NP_077325.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024349.3NP_077325.2  adenylate kinase isoenzyme 1

      See identical proteins and their annotated locations for NP_077325.2

      Status: VALIDATED

      Source sequence(s)
      AABR07051450, BC089797
      UniProtKB/Swiss-Prot
      P39069
      Conserved Domains (2) summary
      TIGR01360
      Location:6193
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:10182
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      11652143..11659135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      10656923..10664139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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