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    Gadd45g growth arrest and DNA-damage-inducible 45 gamma [ Mus musculus (house mouse) ]

    Gene ID: 23882, updated on 23-Oct-2018

    Summary

    Official Symbol
    Gadd45gprovided by MGI
    Official Full Name
    growth arrest and DNA-damage-inducible 45 gammaprovided by MGI
    Primary source
    MGI:MGI:1346325
    See related
    Ensembl:ENSMUSG00000021453 Vega:OTTMUSG00000023076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CR6; DDIT2; OIG37; C86281; AI327420
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 76.7), CNS E14 (RPKM 36.6) and 27 other tissues See more
    Orthologs

    Genomic context

    See Gadd45g in Genome Data Viewer
    Location:
    13; 13 A5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (51846675..51848475)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (51942044..51943844)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene SECIS binding protein 2 Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Neighboring gene RIKEN cDNA 4921525O09 gene Neighboring gene predicted gene, 40948

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    • miRNA regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
      miRNA regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
    • p53 signaling, organism-specific biosystem (from WikiPathways)
      p53 signaling, organism-specific biosystemhttp://www.kegg.jp/ (mmu04115) p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcription...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T-helper 1 cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    activation of MAPKK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of MAPKKK activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of MAPKKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    interferon-gamma biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    growth arrest and DNA damage-inducible protein GADD45 gamma
    Names
    cytokine-responsive protein CR6
    growth arrest and DNA-damage-inducible, gamma

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011817.2NP_035947.2  growth arrest and DNA damage-inducible protein GADD45 gamma

      See identical proteins and their annotated locations for NP_035947.2

      Status: VALIDATED

      Source sequence(s)
      AC126247
      Consensus CDS
      CCDS26515.1
      UniProtKB/TrEMBL
      Q9R0S0
      Related
      ENSMUSP00000021903.2, OTTMUSP00000026704, ENSMUST00000021903.2, OTTMUST00000055694
      Conserved Domains (1) summary
      pfam01248
      Location:24106
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      51846675..51848475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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