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    G3bp2 GTPase activating protein (SH3 domain) binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 23881, updated on 12-Aug-2018

    Summary

    Official Symbol
    G3bp2provided by MGI
    Official Full Name
    GTPase activating protein (SH3 domain) binding protein 2provided by MGI
    Primary source
    MGI:MGI:2442040
    See related
    Ensembl:ENSMUSG00000029405 Vega:OTTMUSG00000055584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G3BP; AA409541; mKIAA0660; E430034L04Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 38.0), whole brain E14.5 (RPKM 34.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See G3bp2 in Genome Data Viewer
    Location:
    5; 5 E2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (92052145..92137737, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (92481172..92512761, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene odontogenesis associated phosphoprotein Neighboring gene cyclin-dependent kinase-like 2 (CDC2-related kinase) Neighboring gene predicted gene, 46915 Neighboring gene predicted gene, 42111 Neighboring gene predicted gene, 46933 Neighboring gene uncharacterized LOC105246914 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene USO1 vesicle docking factor Neighboring gene predicted gene, 42113 Neighboring gene cDNA sequence U90926

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0660

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    stress granule assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ras GTPase-activating protein-binding protein 2
    Names
    Ras-GTPase-activating protein (GAP120) SH3-domain binding protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080794.2NP_001074263.1  ras GTPase-activating protein-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_001074263.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AK153221, AK169571, BY578810, CN527272
      Consensus CDS
      CCDS19427.1
      UniProtKB/Swiss-Prot
      P97379
      UniProtKB/TrEMBL
      Q3TEL4, Q3U541, Q3U6B1
      Related
      ENSMUSP00000128244.1, OTTMUSP00000072427, ENSMUST00000169094.7, OTTMUST00000137562
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326408
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    2. NM_001080795.2NP_001074264.1  ras GTPase-activating protein-binding protein 2 isoform b

      See identical proteins and their annotated locations for NP_001074264.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8 all encode the same isoform (b).
      Source sequence(s)
      AK076117, AK169571, BY272229, BY578810
      Consensus CDS
      CCDS39149.1
      UniProtKB/TrEMBL
      Q3TEL4, Q542W3
      Related
      ENSMUSP00000108752.3, OTTMUSP00000072425, ENSMUST00000113127.6, OTTMUST00000137560
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:293375
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    3. NM_001080796.2NP_001074265.1  ras GTPase-activating protein-binding protein 2 isoform b

      See identical proteins and their annotated locations for NP_001074265.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8 all encode the same isoform (b).
      Source sequence(s)
      AK151732, AK169571, BY578810, CN527272
      Consensus CDS
      CCDS39149.1
      UniProtKB/TrEMBL
      Q3TEL4, Q542W3
      Related
      ENSMUSP00000132469.1, ENSMUST00000167918.7
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:293375
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    4. NM_001080797.2NP_001074266.1  ras GTPase-activating protein-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_001074266.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AK149427, AK169571, BY578810
      Consensus CDS
      CCDS19427.1
      UniProtKB/Swiss-Prot
      P97379
      UniProtKB/TrEMBL
      Q3TEL4, Q3U541
      Related
      ENSMUSP00000128353.1, OTTMUSP00000072426, ENSMUST00000164378.7, OTTMUST00000137561
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326408
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    5. NM_001359195.1NP_001346124.1  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AC122438, AC165433
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326408
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    6. NM_001359196.1NP_001346125.1  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AC122438, AC165433
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326408
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    7. NM_001359197.1NP_001346126.1  ras GTPase-activating protein-binding protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8 all encode the same isoform (b).
      Source sequence(s)
      AC122438, AC165433
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:293375
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    8. NM_011816.4NP_035946.2  ras GTPase-activating protein-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_035946.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AK145697, AK169571, BY272229, BY578810
      Consensus CDS
      CCDS19427.1
      UniProtKB/Swiss-Prot
      P97379
      UniProtKB/TrEMBL
      Q3TEL4, Q3U541
      Related
      ENSMUSP00000144456.1, OTTMUSP00000072428, ENSMUST00000202258.3, OTTMUST00000137563
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326408
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      92052145..92137737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534927.3XP_006534990.1  ras GTPase-activating protein-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      P97379
      UniProtKB/TrEMBL
      Q3U541
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326408
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    2. XM_006534928.3XP_006534991.1  ras GTPase-activating protein-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      P97379
      UniProtKB/TrEMBL
      Q3U541
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326408
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
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