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    Tnpo1 transportin 1 [ Mus musculus (house mouse) ]

    Gene ID: 238799, updated on 9-Sep-2018

    Summary

    Official Symbol
    Tnpo1provided by MGI
    Official Full Name
    transportin 1provided by MGI
    Primary source
    MGI:MGI:2681523
    See related
    Ensembl:ENSMUSG00000009470 Vega:OTTMUSG00000024774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MIP; TRN; IPO2; MIP1; Kpnb2; AU021749; D13Ertd688e
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 23.2), whole brain E14.5 (RPKM 19.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tnpo1 in Genome Data Viewer
    Location:
    13 D1; 13 52.24 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (98839019..98926384, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (99612036..99696339, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene FCH domain only 2 Neighboring gene predicted gene, 34995 Neighboring gene ribosomal protein S17 pseudogene Neighboring gene predicted gene 5453 Neighboring gene predicted gene, 35215 Neighboring gene RIKEN cDNA 1700024P04 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Ran GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    ribosomal protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transportin-1
    Names
    importin beta-2
    karyopherin (importin) beta 2
    karyopherin beta-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048267.1NP_001041732.1  transportin-1 isoform 2

      See identical proteins and their annotated locations for NP_001041732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC129085, AC154849, AK029953, AK030580
      Consensus CDS
      CCDS36760.1
      UniProtKB/Swiss-Prot
      Q8BFY9
      Related
      ENSMUSP00000105026.2, OTTMUSP00000062644, ENSMUST00000109399.8, OTTMUST00000111767
      Conserved Domains (2) summary
      COG5215
      Location:24759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95116
      HEAT; HEAT repeat [structural motif]
    2. NM_178716.3NP_848831.2  transportin-1 isoform 1

      See identical proteins and their annotated locations for NP_848831.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC129085, AK029953, AK030580
      Consensus CDS
      CCDS26717.2
      UniProtKB/Swiss-Prot
      Q8BFY9
      Related
      ENSMUSP00000105028.1, OTTMUSP00000029847, ENSMUST00000109401.7, OTTMUST00000061009
      Conserved Domains (2) summary
      COG5215
      Location:32767
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:103124
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      98839019..98926384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517636.3XP_006517699.1  transportin-1 isoform X1

      See identical proteins and their annotated locations for XP_006517699.1

      UniProtKB/Swiss-Prot
      Q8BFY9
      Conserved Domains (2) summary
      COG5215
      Location:24759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95116
      HEAT; HEAT repeat [structural motif]
    2. XM_006517637.3XP_006517700.1  transportin-1 isoform X1

      See identical proteins and their annotated locations for XP_006517700.1

      UniProtKB/Swiss-Prot
      Q8BFY9
      Conserved Domains (2) summary
      COG5215
      Location:24759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95116
      HEAT; HEAT repeat [structural motif]
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