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    PPIL2 peptidylprolyl isomerase like 2 [ Homo sapiens (human) ]

    Gene ID: 23759, updated on 14-Aug-2021

    Summary

    Official Symbol
    PPIL2provided by HGNC
    Official Full Name
    peptidylprolyl isomerase like 2provided by HGNC
    Primary source
    HGNC:HGNC:9261
    See related
    Ensembl:ENSG00000100023 MIM:607588
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CYC4; CYP60; UBOX7; Cyp-60; hCyP-60
    Summary
    This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in thyroid (RPKM 15.3), lymph node (RPKM 12.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PPIL2 in Genome Data Viewer
    Location:
    22q11.21-q11.22
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (21666010..21700015)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22020301..22054304)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985532 Neighboring gene microRNA 301b Neighboring gene microRNA 130b Neighboring gene yippee like 1 Neighboring gene RNA, 7SL, cytoplasmic 280, pseudogene Neighboring gene mitogen-activated protein kinase 1 Neighboring gene RNA, 5S ribosomal pseudogene 493

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC787, FLJ39930, MGC33174

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables cyclosporin A binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-ubiquitin ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    RING-type E3 ubiquitin-protein ligase PPIL2
    Names
    PPIase
    RING-type E3 ubiquitin transferase isomerase-like 2
    U-box domain containing 7
    cyclophilin, 60kDa
    cyclophilin-60
    cyclophilin-like protein CyP-60
    peptidyl-prolyl cis-trans isomerase-like 2
    peptidylprolyl cis-trans isomerase
    peptidylprolyl isomerase (cyclophilin)-like 2
    probable inactive peptidyl-prolyl cis-trans isomerase-like 2
    rotamase PPIL2
    NP_001304925.1
    NP_055152.1
    NP_680480.1
    NP_680481.1
    XP_005261505.1
    XP_011528343.1
    XP_011528344.1
    XP_011528345.1
    XP_011528346.1
    XP_011528348.1
    XP_011528349.1
    XP_011528351.1
    XP_011528352.1
    XP_011528353.1
    XP_016884194.1
    XP_016884195.1
    XP_024307961.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317996.2NP_001304925.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks a segment in the 3' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (a).
      Source sequence(s)
      AP000553
      Consensus CDS
      CCDS13793.1
      UniProtKB/Swiss-Prot
      Q13356
      UniProtKB/TrEMBL
      A0A024R1C1, A8K0I0
      Related
      ENSP00000506144.1, ENST00000679795.1
      Conserved Domains (4) summary
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
      cd00162
      Location:103146
      RING_Ubox; U-box domain, a modified RING finger [structural motif]
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    2. NM_014337.4NP_055152.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform a

      See identical proteins and their annotated locations for NP_055152.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 4 encode the same isoform (a).
      Source sequence(s)
      AP000553
      Consensus CDS
      CCDS13793.1
      UniProtKB/Swiss-Prot
      Q13356
      UniProtKB/TrEMBL
      A0A024R1C1
      Related
      ENSP00000381812.3, ENST00000398831.8
      Conserved Domains (4) summary
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
      cd00162
      Location:103146
      RING_Ubox; U-box domain, a modified RING finger [structural motif]
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    3. NM_148175.3NP_680480.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform a

      See identical proteins and their annotated locations for NP_680480.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 3' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (a).
      Source sequence(s)
      AA743164, AK127259, AP000553, BC028385, DA863607, U37221
      Consensus CDS
      CCDS13793.1
      UniProtKB/Swiss-Prot
      Q13356
      UniProtKB/TrEMBL
      A0A024R1C1
      Related
      ENSP00000334553.7, ENST00000335025.12
      Conserved Domains (4) summary
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
      cd00162
      Location:103146
      RING_Ubox; U-box domain, a modified RING finger [structural motif]
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    4. NM_148176.3NP_680481.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform b

      See identical proteins and their annotated locations for NP_680481.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate acceptor splice site in the 3' coding region that results in a frameshift compared to variant 1. The encoded isoform (b) contains a longer and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK127259, BC000022, BC028385, DA863607
      Consensus CDS
      CCDS46670.1
      UniProtKB/Swiss-Prot
      Q13356
      Related
      ENSP00000486725.1, ENST00000626352.2
      Conserved Domains (3) summary
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin_RING: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal ...
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      21666010..21700015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005261448.4XP_005261505.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X5

      See identical proteins and their annotated locations for XP_005261505.1

      UniProtKB/Swiss-Prot
      Q13356
      UniProtKB/TrEMBL
      A0A024R1C1
      Related
      ENSP00000506328.1, ENST00000679540.1
      Conserved Domains (4) summary
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
      cd00162
      Location:103146
      RING_Ubox; U-box domain, a modified RING finger [structural motif]
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    2. XM_011530047.3XP_011528349.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X5

      See identical proteins and their annotated locations for XP_011528349.1

      UniProtKB/Swiss-Prot
      Q13356
      UniProtKB/TrEMBL
      A0A024R1C1
      Related
      ENSP00000505910.1, ENST00000680061.1
      Conserved Domains (4) summary
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
      cd00162
      Location:103146
      RING_Ubox; U-box domain, a modified RING finger [structural motif]
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    3. XM_011530046.3XP_011528348.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X5

      See identical proteins and their annotated locations for XP_011528348.1

      UniProtKB/Swiss-Prot
      Q13356
      UniProtKB/TrEMBL
      A0A024R1C1
      Conserved Domains (4) summary
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
      cd00162
      Location:103146
      RING_Ubox; U-box domain, a modified RING finger [structural motif]
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    4. XM_011530042.3XP_011528344.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X2

      Related
      ENSP00000505107.1, ENST00000681338.1
      Conserved Domains (4) summary
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
      cd00162
      Location:103146
      RING_Ubox; U-box domain, a modified RING finger [structural motif]
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    5. XM_011530044.3XP_011528346.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X4

      Conserved Domains (4) summary
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
      cd00162
      Location:103146
      RING_Ubox; U-box domain, a modified RING finger [structural motif]
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    6. XM_011530043.3XP_011528345.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X3

      Conserved Domains (4) summary
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
      cd00162
      Location:103146
      RING_Ubox; U-box domain, a modified RING finger [structural motif]
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    7. XM_011530041.3XP_011528343.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X1

      Related
      ENSP00000506368.1, ENST00000680094.1
      Conserved Domains (4) summary
      cd01923
      Location:281440
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
      cd00162
      Location:103146
      RING_Ubox; U-box domain, a modified RING finger [structural motif]
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    8. XM_024452193.1XP_024307961.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X7

      Related
      ENSP00000506723.1, ENST00000679580.1
      Conserved Domains (4) summary
      cd00162
      Location:103146
      RING_Ubox; U-box domain, a modified RING finger [structural motif]
      cd16663
      Location:38110
      RING-Ubox_PPIL2; U-box domain, a modified RING finger, found in peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and similar proteins
      cl00197
      Location:281401
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
      cl17238
      Location:100159
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    9. XM_011530049.2XP_011528351.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X6

      See identical proteins and their annotated locations for XP_011528351.1

      Conserved Domains (1) summary
      cd01923
      Location:103262
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
    10. XM_011530050.2XP_011528352.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X6

      See identical proteins and their annotated locations for XP_011528352.1

      Conserved Domains (1) summary
      cd01923
      Location:103262
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
    11. XM_011530051.2XP_011528353.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X6

      See identical proteins and their annotated locations for XP_011528353.1

      Conserved Domains (1) summary
      cd01923
      Location:103262
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
    12. XM_017028706.2XP_016884195.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X9

      Related
      ENST00000446951.1
      Conserved Domains (1) summary
      cd01923
      Location:27186
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
    13. XM_017028705.1XP_016884194.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X8

      Conserved Domains (1) summary
      cd01923
      Location:27186
      cyclophilin_RING; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal cyclophilin Human ...
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