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    DAPK2 death associated protein kinase 2 [ Homo sapiens (human) ]

    Gene ID: 23604, updated on 5-Aug-2018

    Summary

    Official Symbol
    DAPK2provided by HGNC
    Official Full Name
    death associated protein kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:2675
    See related
    Ensembl:ENSG00000035664 MIM:616567; Vega:OTTHUMG00000132947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRP1; DRP-1
    Summary
    This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in thyroid (RPKM 7.0), lung (RPKM 4.4) and 18 other tissues See more
    Orthologs

    Genomic context

    See DAPK2 in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (63907036..64046470, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64199235..64363614, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Neighboring gene microRNA 422a Neighboring gene uncharacterized LOC101928988 Neighboring gene cytosolic iron-sulfur assembly component 2A Neighboring gene sorting nexin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of death-associated protein kinase 2 (DAPK2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Bladder Cancer, organism-specific biosystem (from WikiPathways)
      Bladder Cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Caspase activation via extrinsic apoptotic signalling pathway, organism-specific biosystem (from REACTOME)
      Caspase activation via extrinsic apoptotic signalling pathway, organism-specific biosystemKnown as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, ...
    • Ligand-independent caspase activation via DCC, organism-specific biosystem (from REACTOME)
      Ligand-independent caspase activation via DCC, organism-specific biosystemIn the presence of Netrin1, DCC and UNC5 generate attractive and repulsive signals to growing axons. In the absence of Netrin-1, DCC induces cell death signaling initiated via caspase cleavage of DCC...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
      Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC119312

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    anoikis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neutrophil migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of eosinophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of autophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    autophagosome lumen IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    death-associated protein kinase 2
    Names
    DAP kinase 2
    DAP-kinase-related protein 1 beta isoform
    NP_055141.2
    XP_011519715.1
    XP_011519716.1
    XP_011519717.1
    XP_011519718.1
    XP_011519719.1
    XP_011519723.1
    XP_016877532.1
    XP_016877533.1
    XP_016877534.1
    XP_016877535.1
    XP_016877536.1
    XP_016877537.1
    XP_016877538.1
    XP_016877539.1
    XP_016877540.1
    XP_016877541.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363730.1NP_001350659.1  death-associated protein kinase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC015914, AC021541, GU056176
      Consensus CDS
      CCDS86463.1
      Conserved Domains (1) summary
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
    2. NM_014326.4NP_055141.2  death-associated protein kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_055141.2

      Status: VALIDATED

      Source sequence(s)
      AB018001, AC015914, AC021541, AF052941
      Consensus CDS
      CCDS10188.1
      UniProtKB/Swiss-Prot
      Q9UIK4
      UniProtKB/TrEMBL
      A0A024R603
      Related
      ENSP00000408277.1, OTTHUMP00000163874, ENST00000457488.5
      Conserved Domains (1) summary
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

      Range
      63907036..64046470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521421.3XP_011519723.1  death-associated protein kinase 2 isoform X10

      Conserved Domains (2) summary
      smart00220
      Location:2130
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1130
      PKc_like; Protein Kinases, catalytic domain
    2. XM_011521417.1XP_011519719.1  death-associated protein kinase 2 isoform X7

      See identical proteins and their annotated locations for XP_011519719.1

      Conserved Domains (2) summary
      smart00220
      Location:23279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:17279
      PKc_like; Protein Kinases, catalytic domain
    3. XM_017022045.1XP_016877534.1  death-associated protein kinase 2 isoform X7

      Conserved Domains (2) summary
      smart00220
      Location:23279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:17279
      PKc_like; Protein Kinases, catalytic domain
    4. XM_011521413.2XP_011519715.1  death-associated protein kinase 2 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:23285
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
    5. XM_017022044.1XP_016877533.1  death-associated protein kinase 2 isoform X6

    6. XM_011521414.1XP_011519716.1  death-associated protein kinase 2 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:23285
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
    7. XM_017022046.1XP_016877535.1  death-associated protein kinase 2 isoform X7

      Conserved Domains (2) summary
      smart00220
      Location:23279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:17279
      PKc_like; Protein Kinases, catalytic domain
    8. XM_011521415.3XP_011519717.1  death-associated protein kinase 2 isoform X5

      Conserved Domains (2) summary
      smart00220
      Location:23285
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
    9. XM_017022043.1XP_016877532.1  death-associated protein kinase 2 isoform X1

    10. XM_017022049.1XP_016877538.1  death-associated protein kinase 2 isoform X8

    11. XM_017022047.1XP_016877536.1  death-associated protein kinase 2 isoform X8

    12. XM_017022050.1XP_016877539.1  death-associated protein kinase 2 isoform X8

    13. XM_017022051.1XP_016877540.1  death-associated protein kinase 2 isoform X8

    14. XM_017022048.2XP_016877537.1  death-associated protein kinase 2 isoform X8

    15. XM_017022052.1XP_016877541.1  death-associated protein kinase 2 isoform X9

    16. XM_011521416.2XP_011519718.1  death-associated protein kinase 2 isoform X3

      UniProtKB/Swiss-Prot
      Q9UIK4
      Related
      ENSP00000484390.1, OTTHUMP00000248595, ENST00000612884.4, OTTHUMT00000418543
      Conserved Domains (1) summary
      cd14196
      Location:17285
      STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
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