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    CORO1C coronin 1C [ Homo sapiens (human) ]

    Gene ID: 23603, updated on 4-Jul-2021

    Summary

    Official Symbol
    CORO1Cprovided by HGNC
    Official Full Name
    coronin 1Cprovided by HGNC
    Primary source
    HGNC:HGNC:2254
    See related
    Ensembl:ENSG00000110880 MIM:605269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCRNN4
    Summary
    This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
    Expression
    Ubiquitous expression in endometrium (RPKM 30.8), lung (RPKM 27.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CORO1C in Genome Data Viewer
    Location:
    12q24.11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (108645109..108759955, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109038885..109125294, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369968 Neighboring gene selectin P ligand Neighboring gene microRNA 4496 Neighboring gene RNA, U7 small nuclear 169 pseudogene Neighboring gene Sharpr-MPRA regulatory region 839 Neighboring gene uncharacterized LOC105369969 Neighboring gene uncharacterized LOC101929204 Neighboring gene slingshot protein phosphatase 1 Neighboring gene microRNA 619

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    GeneReviews: Not available
    Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in activation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in endosomal transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endosome fission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endosome membrane tubulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in establishment of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane fission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phagocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of lamellipodium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of epithelial cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of fibroblast migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of focal adhesion assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of ruffle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of substrate adhesion-dependent cell spreading IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of flotillin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in focal adhesion HDA PubMed 
    NOT colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    coronin-1C
    Names
    coronin, actin binding protein, 1C
    coronin-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105237.2NP_001098707.1  coronin-1C isoform a

      See identical proteins and their annotated locations for NP_001098707.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC007569, AM849478, BM677390
      Consensus CDS
      CCDS61236.1
      UniProtKB/Swiss-Prot
      Q9ULV4
      Related
      ENSP00000394496.2, ENST00000420959.6
      Conserved Domains (5) summary
      pfam05873
      Location:471527
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
      pfam08953
      Location:59116
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:396438
      WD40_4; Type of WD40 repeat
      sd00039
      Location:89131
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:128353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001276471.2NP_001263400.1  coronin-1C isoform b

      See identical proteins and their annotated locations for NP_001263400.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate first exon and initiates translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC007569, AK096363, BM677390
      Consensus CDS
      CCDS9120.1
      UniProtKB/Swiss-Prot
      Q9ULV4
      UniProtKB/TrEMBL
      A0A024RBI5
      Related
      ENSP00000438341.1, ENST00000541050.5
      Conserved Domains (3) summary
      sd00039
      Location:3678
      7WD40; WD40 repeat [structural motif]
      pfam05873
      Location:418474
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
      cl25676
      Location:8402
      WD40_4; Type of WD40 repeat
    3. NM_014325.4NP_055140.1  coronin-1C isoform b

      See identical proteins and their annotated locations for NP_055140.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate first exon and initiates translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AB030656, AC007569, BM677390
      Consensus CDS
      CCDS9120.1
      UniProtKB/Swiss-Prot
      Q9ULV4
      UniProtKB/TrEMBL
      A0A024RBI5
      Related
      ENSP00000261401.3, ENST00000261401.8
      Conserved Domains (3) summary
      sd00039
      Location:3678
      7WD40; WD40 repeat [structural motif]
      pfam05873
      Location:418474
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
      cl25676
      Location:8402
      WD40_4; Type of WD40 repeat

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      108645109..108759955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448916.1XP_024304684.1  coronin-1C isoform X1

      Conserved Domains (3) summary
      sd00039
      Location:3678
      7WD40; WD40 repeat [structural motif]
      pfam05873
      Location:418474
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
      cl25676
      Location:8402
      WD40_4; Type of WD40 repeat
    2. XM_024448915.1XP_024304683.1  coronin-1C isoform X1

      Conserved Domains (3) summary
      sd00039
      Location:3678
      7WD40; WD40 repeat [structural motif]
      pfam05873
      Location:418474
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
      cl25676
      Location:8402
      WD40_4; Type of WD40 repeat
    3. XM_017019122.2XP_016874611.1  coronin-1C isoform X1

      UniProtKB/Swiss-Prot
      Q9ULV4
      UniProtKB/TrEMBL
      A0A024RBI5
      Conserved Domains (3) summary
      sd00039
      Location:3678
      7WD40; WD40 repeat [structural motif]
      pfam05873
      Location:418474
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
      cl25676
      Location:8402
      WD40_4; Type of WD40 repeat
    4. XM_017019121.2XP_016874610.1  coronin-1C isoform X2

      UniProtKB/Swiss-Prot
      Q9ULV4
      Conserved Domains (5) summary
      pfam05873
      Location:471527
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
      pfam08953
      Location:59116
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:396438
      WD40_4; Type of WD40 repeat
      sd00039
      Location:89131
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:128353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_017019123.2XP_016874612.1  coronin-1C isoform X1

      UniProtKB/Swiss-Prot
      Q9ULV4
      UniProtKB/TrEMBL
      A0A024RBI5
      Conserved Domains (3) summary
      sd00039
      Location:3678
      7WD40; WD40 repeat [structural motif]
      pfam05873
      Location:418474
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
      cl25676
      Location:8402
      WD40_4; Type of WD40 repeat
    6. XM_024448914.1XP_024304682.1  coronin-1C isoform X1

      Conserved Domains (3) summary
      sd00039
      Location:3678
      7WD40; WD40 repeat [structural motif]
      pfam05873
      Location:418474
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
      cl25676
      Location:8402
      WD40_4; Type of WD40 repeat
    7. XM_011538125.1XP_011536427.1  coronin-1C isoform X4

      Conserved Domains (2) summary
      pfam05873
      Location:230286
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
      pfam16300
      Location:155197
      WD40_4; Type of WD40 repeat
    8. XM_024448917.1XP_024304685.1  coronin-1C isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:89131
      7WD40; WD40 repeat [structural motif]
      cl25676
      Location:61354
      WD40_4; Type of WD40 repeat

    RNA

    1. XR_944514.2 RNA Sequence

    2. XR_001748650.1 RNA Sequence

    3. XR_002957304.1 RNA Sequence

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