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    Apeh acylpeptide hydrolase [ Mus musculus (house mouse) ]

    Gene ID: 235606, updated on 27-Jan-2018

    Summary

    Official Symbol
    Apehprovided by MGI
    Official Full Name
    acylpeptide hydrolaseprovided by MGI
    Primary source
    MGI:MGI:88041
    See related
    Ensembl:ENSMUSG00000032590 Vega:OTTMUSG00000050818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in kidney adult (RPKM 71.8), liver E14.5 (RPKM 55.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Apeh in Genome Data Viewer
    Location:
    9 F1; 9 59.07 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (108085414..108094554, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (107987745..107996811, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig like domain 3 Neighboring gene microRNA 7088 Neighboring gene macrophage stimulating 1 (hepatocyte growth factor-like) Neighboring gene predicted gene, 46132 Neighboring gene bassoon Neighboring gene RIKEN cDNA 4930447F24 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC38101

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    omega peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    amyloid-beta metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acylamino-acid-releasing enzyme
    Names
    AARE
    APH
    N-acylaminoacyl peptide hydrolase
    acyl-peptide hydrolase
    acylaminoacyl-peptidase
    NP_666338.2
    XP_006511786.1
    XP_006511787.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146226.2NP_666338.2  acylamino-acid-releasing enzyme

      See identical proteins and their annotated locations for NP_666338.2

      Status: VALIDATED

      Source sequence(s)
      AI845932, AK149713, BB737329, CJ134183
      Consensus CDS
      CCDS52923.1
      UniProtKB/Swiss-Prot
      Q8R146
      Related
      ENSMUSP00000141856.1, OTTMUSP00000069250, ENSMUST00000193254.5, OTTMUST00000128772
      Conserved Domains (2) summary
      pfam00561
      Location:501713
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:510707
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      108085414..108094554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511723.3XP_006511786.1  acylamino-acid-releasing enzyme isoform X1

      Conserved Domains (2) summary
      pfam00561
      Location:366578
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:375572
      Abhydrolase; alpha/beta hydrolases
    2. XM_006511724.3XP_006511787.1  acylamino-acid-releasing enzyme isoform X2

      Conserved Domains (1) summary
      COG0823
      Location:258404
      TolB; Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport]
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