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    Map3k21 mitogen-activated protein kinase kinase kinase 21 [ Mus musculus (house mouse) ]

    Gene ID: 234878, updated on 9-Sep-2018

    Summary

    Official Symbol
    Map3k21provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase 21provided by MGI
    Primary source
    MGI:MGI:2385307
    See related
    Ensembl:ENSMUSG00000031853 Vega:OTTMUSG00000061596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mlk4; mKIAA1804
    Expression
    Broad expression in colon adult (RPKM 9.7), large intestine adult (RPKM 6.1) and 16 other tissues See more
    Orthologs

    Genomic context

    See Map3k21 in Genome Data Viewer
    Location:
    8; 8 E2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (125910450..125947440)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (128434350..128471339)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene pecanex homolog 2 Neighboring gene predicted gene, 46061 Neighboring gene RIKEN cDNA A730098A19 gene Neighboring gene predicted gene, 31069 Neighboring gene predicted gene, 42056

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Homology

    Clone Names

    • KIAA1804, MGC27778

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    JUN kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 21; mitogen-activated protein kinase kinase kinase MLK4
    Names
    mixed lineage kinase 4
    NP_663583.2
    XP_006531034.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145608.2NP_663583.2  mitogen-activated protein kinase kinase kinase 21

      See identical proteins and their annotated locations for NP_663583.2

      Status: VALIDATED

      Source sequence(s)
      AC102420, AC105066
      Consensus CDS
      CCDS40519.1
      UniProtKB/Swiss-Prot
      Q8VDG6
      Related
      ENSMUSP00000034316.4, OTTMUSP00000077904, ENSMUST00000034316.5, OTTMUST00000150267
      Conserved Domains (3) summary
      smart00219
      Location:110382
      TyrKc; Tyrosine kinase, catalytic domain
      cl17036
      Location:2882
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:115385
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      125910450..125947440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530971.1XP_006531034.1  mitogen-activated protein kinase kinase kinase MLK4 isoform X1

      Conserved Domains (1) summary
      TIGR03319
      Location:381
      RNase_Y; ribonuclease Y
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