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    Mat2a methionine adenosyltransferase II, alpha [ Mus musculus (house mouse) ]

    Gene ID: 232087, updated on 5-Aug-2018

    Summary

    Official Symbol
    Mat2aprovided by MGI
    Official Full Name
    methionine adenosyltransferase II, alphaprovided by MGI
    Primary source
    MGI:MGI:2443731
    See related
    Ensembl:ENSMUSG00000053907 Vega:OTTMUSG00000057919
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MAT 2; D630045P18Rik
    Expression
    Ubiquitous expression in CNS E14 (RPKM 103.5), whole brain E14.5 (RPKM 90.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See Mat2a in Genome Data Viewer
    Location:
    6; 6 C1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (72432799..72439558, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (72382793..72389552, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein 8 Neighboring gene gamma-glutamyl carboxylase Neighboring gene promoter of Mat2a antisense radiation induced circulating long non-coding RNA Neighboring gene SH2 domain containing 6 Neighboring gene capping protein (actin filament), gelsolin-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6545

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methionine adenosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methionine adenosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methionine adenosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    S-adenosylmethionine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    S-adenosylmethionine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein hexamerization ISO
    Inferred from Sequence Orthology
    more info
     
    response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    methionine adenosyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methionine adenosyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    S-adenosylmethionine synthase isoform type-2
    Names
    S-adenosylmethionine synthetase isoform type-2
    adoMet synthase 2
    adoMet synthetase 2
    methionine adenosyltransferase 2
    NP_663544.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363798.1NP_001350727.1  S-adenosylmethionine synthase isoform type-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK160869, BC058360
      Conserved Domains (1) summary
      cl27369
      Location:16362
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain
    2. NM_001363799.1NP_001350728.1  S-adenosylmethionine synthase isoform type-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK133960, BC058360
      Conserved Domains (1) summary
      cl27369
      Location:16364
      S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain
    3. NM_145569.5NP_663544.1  S-adenosylmethionine synthase isoform type-2 isoform 1

      See identical proteins and their annotated locations for NP_663544.1

      Status: VALIDATED

      Source sequence(s)
      AC116115
      Consensus CDS
      CCDS39515.1
      UniProtKB/Swiss-Prot
      Q3THS6
      UniProtKB/TrEMBL
      Q99J57
      Related
      ENSMUSP00000087118.6, OTTMUSP00000074229, ENSMUST00000059472.9
      Conserved Domains (1) summary
      PTZ00104
      Location:16395
      PTZ00104; S-adenosylmethionine synthase; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      72432799..72439558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 PATCHES

    Genomic

    1. NW_006763129.1 Reference GRCm38.p4 PATCHES

      Range
      136082..142841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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