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    FAM168A family with sequence similarity 168 member A [ Homo sapiens (human) ]

    Gene ID: 23201, updated on 7-Oct-2018

    Summary

    Official Symbol
    FAM168Aprovided by HGNC
    Official Full Name
    family with sequence similarity 168 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:28999
    See related
    Ensembl:ENSG00000054965 MIM:616316; Vega:OTTHUMG00000167995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCRP1; KIAA0280
    Expression
    Ubiquitous expression in brain (RPKM 45.1), gall bladder (RPKM 10.1) and 24 other tissues See more
    Orthologs

    Genomic context

    See FAM168A in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (73400478..73598189, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73111837..73309234, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100287837 Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene RELT, TNF receptor Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 38 Neighboring gene MIA SH3 domain ER export factor 2 pseudogene Neighboring gene pleckstrin homology domain containing B1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0280

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of base-excision repair IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein FAM168A
    Names
    tongue cancer chemotherapy resistance-associated protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286050.1NP_001272979.1  protein FAM168A isoform 1

      See identical proteins and their annotated locations for NP_001272979.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AP000763, BC052341, D87470, DB074440
      Consensus CDS
      CCDS73346.1
      UniProtKB/Swiss-Prot
      Q92567
      Related
      ENSP00000064778.4, OTTHUMP00000237537, ENST00000064778.8, OTTHUMT00000397424
      Conserved Domains (1) summary
      pfam14944
      Location:1244
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
    2. NM_001286051.1NP_001272980.1  protein FAM168A isoform 3

      See identical proteins and their annotated locations for NP_001272980.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AP000763, DB074440, EF197985
      Consensus CDS
      CCDS66165.1
      UniProtKB/Swiss-Prot
      Q92567
      Related
      ENSP00000390501.2, OTTHUMP00000237538, ENST00000450446.6, OTTHUMT00000397425
      Conserved Domains (1) summary
      pfam14944
      Location:1129
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
    3. NM_015159.2NP_055974.1  protein FAM168A isoform 2

      See identical proteins and their annotated locations for NP_055974.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AP000763, BC052341, DB074440
      Consensus CDS
      CCDS41689.1
      UniProtKB/Swiss-Prot
      Q92567
      Related
      ENSP00000348852.4, OTTHUMP00000237539, ENST00000356467.4, OTTHUMT00000397426
      Conserved Domains (1) summary
      pfam14944
      Location:1235
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      73400478..73598189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017415.2XP_016872904.1  protein FAM168A isoform X1

      Conserved Domains (1) summary
      pfam14944
      Location:1193
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
    2. XM_017017416.2XP_016872905.1  protein FAM168A isoform X2

      Conserved Domains (1) summary
      pfam14944
      Location:1138
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
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