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    Zmpste24 zinc metallopeptidase, STE24 [ Mus musculus (house mouse) ]

    Gene ID: 230709, updated on 5-Mar-2019

    Summary

    Official Symbol
    Zmpste24provided by MGI
    Official Full Name
    zinc metallopeptidase, STE24provided by MGI
    Primary source
    MGI:MGI:1890508
    See related
    Ensembl:ENSMUSG00000043207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MADB; FACE1; STE24; Face-1; Ste24p; D030046F19; A530043O15Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 16.8), placenta adult (RPKM 12.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Zmpste24 in Genome Data Viewer
    Location:
    4; 4 D2.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (121059237..121098249, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (120731843..120770848, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene small ArfGAP 2 Neighboring gene microRNA 7015 Neighboring gene collagen, type IX, alpha 2 Neighboring gene transmembrane and coiled-coil domains 2 Neighboring gene predicted gene 12882

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Adipogenesis genes, organism-specific biosystem (from WikiPathways)
      Adipogenesis genes, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
    • Terpenoid backbone biosynthesis, organism-specific biosystem (from KEGG)
      Terpenoid backbone biosynthesis, organism-specific biosystemTerpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mev...
    • Terpenoid backbone biosynthesis, conserved biosystem (from KEGG)
      Terpenoid backbone biosynthesis, conserved biosystemTerpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mev...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    double-stranded DNA binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metalloendopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    CAAX-box protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    CAMKK-AMPK signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA repair IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone mineralization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    calcium ion import into sarcoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth plate cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H2A phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H2B acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H2B-K5 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hypomethylation of CpG island IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of rDNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of production of miRNAs involved in gene silencing by miRNA IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of production of miRNAs involved in gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear envelope organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    nuclear envelope organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleus organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prenylated protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of DNA damage response, signal transduction by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of RNA polymerase II regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of blood circulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of bone mineralization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cellular senescence IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of histone H4 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of histone H4-K16 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of hormone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic cell cycle DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of stress-activated protein kinase signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of termination of RNA polymerase I transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ventricular cardiac muscle cell membrane repolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thymus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    CAAX prenyl protease 1 homolog
    Names
    farnesylated-proteins converting enzyme 1
    prenyl protein-specific endoprotease 1
    zinc metallopeptidase, STE24 homolog
    zinc metalloproteinase, STE24 homolog
    NP_766288.1
    XP_006503082.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172700.3NP_766288.1  CAAX prenyl protease 1 homolog

      See identical proteins and their annotated locations for NP_766288.1

      Status: VALIDATED

      Source sequence(s)
      AL669949
      Consensus CDS
      CCDS18600.1
      UniProtKB/Swiss-Prot
      Q80W54
      UniProtKB/TrEMBL
      B9EHY2
      Related
      ENSMUSP00000053900.2, ENSMUST00000058754.8
      Conserved Domains (3) summary
      COG0501
      Location:124474
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      pfam01435
      Location:228471
      Peptidase_M48; Peptidase family M48
      pfam16491
      Location:41225
      Peptidase_M48_N; CAAX prenyl protease N-terminal, five membrane helices

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      121059237..121098249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503019.1XP_006503082.1  CAAX prenyl protease 1 homolog isoform X1

      See identical proteins and their annotated locations for XP_006503082.1

      Conserved Domains (3) summary
      COG0501
      Location:143493
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      pfam01435
      Location:247490
      Peptidase_M48; Peptidase family M48
      pfam16491
      Location:41244
      Peptidase_M48_N; CAAX prenyl protease N-terminal, five membrane helices
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