Format

Send to:

Choose Destination
    • Showing Current items.

    Nrd1 nardilysin, N-arginine dibasic convertase, NRD convertase 1 [ Mus musculus (house mouse) ]

    Gene ID: 230598, updated on 12-Aug-2018

    Summary

    Official Symbol
    Nrd1provided by MGI
    Official Full Name
    nardilysin, N-arginine dibasic convertase, NRD convertase 1provided by MGI
    Primary source
    MGI:MGI:1201386
    See related
    Ensembl:ENSMUSG00000053510 Vega:OTTMUSG00000008296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nrdc; NRD-C; AI875733; 2600011I06Rik
    Expression
    Broad expression in testis adult (RPKM 91.8), CNS E11.5 (RPKM 25.7) and 22 other tissues See more
    Orthologs

    Genomic context

    See Nrd1 in Genome Data Viewer
    Location:
    4; 4 C7
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (109000614..109061771)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (108673410..108734376)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 12 (endoplasmic reticulum) Neighboring gene KTI12 homolog, chromatin associated Neighboring gene RAB3B, member RAS oncogene family Neighboring gene RIKEN cDNA 8030443G20 gene Neighboring gene microRNA 761 Neighboring gene oxysterol binding protein-like 9 Neighboring gene predicted gene, 32581 Neighboring gene predicted gene, 46867

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25477

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nardilysin
    Names
    N-arginine dibasic convertase
    NRD convertase
    nardilysin convertase
    NP_666262.2
    XP_006503053.1
    XP_006503054.1
    XP_017175633.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346554.1NP_001333483.1  nardilysin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL627406, BE949999
      UniProtKB/TrEMBL
      A6PWC3
    2. NM_001347169.2NP_001334098.1  nardilysin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL627406, BE949999
      Consensus CDS
      CCDS84773.1
      UniProtKB/TrEMBL
      A2A9Q2
    3. NM_146150.3NP_666262.2  nardilysin isoform 2 precursor

      See identical proteins and their annotated locations for NP_666262.2

      Status: VALIDATED

      Source sequence(s)
      AK031548, BY732391, CF168810
      Consensus CDS
      CCDS18460.1
      UniProtKB/Swiss-Prot
      Q8BHG1
      Related
      ENSMUSP00000068328.4, OTTMUSP00000008673, ENSMUST00000065977.10
      Conserved Domains (4) summary
      COG1025
      Location:2221100
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:210348
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:373559
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:564845
      Peptidase_M16_M; Middle or third domain of peptidase_M16

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      109000614..109061771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502991.3XP_006503054.1  nardilysin isoform X2

      Conserved Domains (4) summary
      COG1025
      Location:2901152
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:290416
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:441627
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:632913
      Peptidase_M16_M; Middle or third domain of peptidase_M16
    2. XM_006502990.3XP_006503053.1  nardilysin isoform X1

      Related
      ENSMUSP00000102255.2, OTTMUSP00000008674, ENSMUST00000106644.8, OTTMUST00000018881
      Conserved Domains (4) summary
      COG1025
      Location:2901168
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:290416
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:441627
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:632913
      Peptidase_M16_M; Middle or third domain of peptidase_M16
    3. XM_017320144.1XP_017175633.1  nardilysin isoform X3

    RNA

    1. XR_001784119.1 RNA Sequence

    2. XR_001784120.1 RNA Sequence

    3. XR_001784121.1 RNA Sequence

    Support Center