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    FOXM1 forkhead box M1 [ Homo sapiens (human) ]

    Gene ID: 2305, updated on 14-Oct-2018

    Summary

    Official Symbol
    FOXM1provided by HGNC
    Official Full Name
    forkhead box M1provided by HGNC
    Primary source
    HGNC:HGNC:3818
    See related
    Ensembl:ENSG00000111206 MIM:602341; Vega:OTTHUMG00000168118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MPP2; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11; TRIDENT; MPHOSPH2
    Summary
    The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
    Expression
    Broad expression in testis (RPKM 16.1), bone marrow (RPKM 11.2) and 16 other tissues See more
    Orthologs

    Genomic context

    See FOXM1 in Genome Data Viewer
    Location:
    12p13.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (2857680..2877155, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (2966846..2986321, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene testis expressed 52 Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 Neighboring gene tubby like protein 3 Neighboring gene RNA, U6 small nuclear 1315, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell cycle TAS
    Traceable Author Statement
    more info
     
    regulation of cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    forkhead box protein M1
    Names
    Forkhead, drosophila, homolog-like 16
    HNF-3/fork-head homolog 11
    M-phase phosphoprotein 2
    MPM-2 reactive phosphoprotein 2
    a novel forkhead box M1 isoform FOXM1D
    forkhead-related protein FKHL16
    hepatocyte nuclear factor 3 forkhead homolog 11
    transcription factor Trident
    winged-helix factor from INS-1 cells

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029590.1 RefSeqGene

      Range
      5001..24475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243088.1NP_001230017.1  forkhead box protein M1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK313845, AW780338, DB137846, U74612
      Consensus CDS
      CCDS76506.1
      UniProtKB/Swiss-Prot
      Q08050
      UniProtKB/TrEMBL
      A0A0D9SFF0
      Related
      ENSP00000486536.1, ENST00000627656.2
      Conserved Domains (1) summary
      cd00059
      Location:235310
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    2. NM_001243089.1NP_001230018.1  forkhead box protein M1 isoform 5

      See identical proteins and their annotated locations for NP_001230018.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK291206, AW780338, DB137846, U83113
      UniProtKB/Swiss-Prot
      Q08050
      UniProtKB/TrEMBL
      A8K591
      Conserved Domains (1) summary
      cd00059
      Location:235310
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    3. NM_021953.3NP_068772.2  forkhead box protein M1 isoform 2

      See identical proteins and their annotated locations for NP_068772.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AW780338, DB137846, U83113
      Consensus CDS
      CCDS8515.1
      UniProtKB/Swiss-Prot
      Q08050
      UniProtKB/TrEMBL
      Q53Y49
      Related
      ENSP00000352901.3, OTTHUMP00000237985, ENST00000359843.7, OTTHUMT00000398272
      Conserved Domains (2) summary
      cd00059
      Location:236311
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      cl28033
      Location:402711
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    4. NM_202002.2NP_973731.1  forkhead box protein M1 isoform 1

      See identical proteins and their annotated locations for NP_973731.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AW780338, DB137846, U74612
      Consensus CDS
      CCDS8516.1
      UniProtKB/Swiss-Prot
      Q08050
      Related
      ENSP00000342307.2, OTTHUMP00000237983, ENST00000342628.6, OTTHUMT00000398270
      Conserved Domains (2) summary
      cd00059
      Location:236311
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      cl28033
      Location:504749
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    5. NM_202003.2NP_973732.1  forkhead box protein M1 isoform 3

      See identical proteins and their annotated locations for NP_973732.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AW780338, DB137846, U74613
      Consensus CDS
      CCDS8517.1
      UniProtKB/Swiss-Prot
      Q08050
      Related
      ENSP00000354492.3, OTTHUMP00000237984, ENST00000361953.7, OTTHUMT00000398271
      Conserved Domains (1) summary
      cd00059
      Location:236311
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      2857680..2877155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520930.3XP_011519232.1  forkhead box protein M1 isoform X2

      Conserved Domains (1) summary
      cd00059
      Location:235310
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    2. XM_011520931.3XP_011519233.1  forkhead box protein M1 isoform X3

      Conserved Domains (1) summary
      cd00059
      Location:236311
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    3. XM_005253676.4XP_005253733.1  forkhead box protein M1 isoform X1

      Conserved Domains (1) summary
      cd00059
      Location:236311
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    4. XM_011520934.3XP_011519236.1  forkhead box protein M1 isoform X6

      Conserved Domains (1) summary
      cd00059
      Location:236311
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    5. XM_011520935.1XP_011519237.1  forkhead box protein M1 isoform X7

      Conserved Domains (1) summary
      cd00059
      Location:236311
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    6. XM_011520933.1XP_011519235.1  forkhead box protein M1 isoform X5

      Conserved Domains (1) summary
      cd00059
      Location:236311
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    7. XM_011520932.1XP_011519234.1  forkhead box protein M1 isoform X4

      Conserved Domains (1) summary
      cd00059
      Location:236311
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

    RNA

    1. XR_931507.1 RNA Sequence

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