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    FKBP4 FK506 binding protein 4 [ Homo sapiens (human) ]

    Gene ID: 2288, updated on 8-Jul-2018
    Official Symbol
    FKBP4provided by HGNC
    Official Full Name
    FK506 binding protein 4provided by HGNC
    Primary source
    HGNC:HGNC:3720
    See related
    Ensembl:ENSG00000004478 MIM:600611; Vega:OTTHUMG00000090429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase
    Summary
    The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
    Expression
    Ubiquitous expression in testis (RPKM 24.9), kidney (RPKM 21.3) and 25 other tissues See more
    Orthologs
    See FKBP4 in Genome Data Viewer
    Location:
    12p13.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (2794942..2805423)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (2904108..2914589)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ITFG2 antisense RNA 1 Neighboring gene ribosomal protein L23a pseudogene 14 Neighboring gene chromobox 3 pseudogene 4 Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene testis expressed 52

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat upregulates the abundance of FK506 binding protein 4 (FKBP4) in the nucleoli of Jurkat T-cells PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human FK506 binding protein 4, 59kDa (FKBP4) at amino acid residues 21-22 by the HIV-1 protease PubMed
    gag-pol HIV-1 PR is identified to have a physical interaction with FK506 binding protein 4 (FKBP4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
    • Attenuation phase, organism-specific biosystem (from REACTOME)
      Attenuation phase, organism-specific biosystemAttenuation of the heat shock transcriptional response occurs during continuous exposure to intermediate heat shock conditions or upon recovery from stress (Abravaya et al. 1991). The attenuation pha...
    • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
      Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Coregulation of Androgen receptor activity, organism-specific biosystem
      Coregulation of Androgen receptor activity
    • Estrogen signaling pathway, organism-specific biosystem (from KEGG)
      Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
    • Estrogen signaling pathway, conserved biosystem (from KEGG)
      Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
    • HSF1-dependent transactivation, organism-specific biosystem (from REACTOME)
      HSF1-dependent transactivation, organism-specific biosystemAcquisition of DNA binding activity by HSF1 is necessary but insufficient for transcriptional activation (Cotto JJ et al. 1996; Trinklein ND et al. 2004). In addition to having a sequence-specific DN...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    FK506 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    FK506 binding TAS
    Traceable Author Statement
    more info
    PubMed 
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding HDA PubMed 
    copper-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    glucocorticoid receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphoprotein binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging TAS
    Traceable Author Statement
    more info
    PubMed 
    tau protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    androgen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    copper ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    embryo implantation IEA
    Inferred from Electronic Annotation
    more info
     
    male sex differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of microtubule polymerization or depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    prostate gland development IEA
    Inferred from Electronic Annotation
    more info
     
    protein folding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex localization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cellular response to heat TAS
    Traceable Author Statement
    more info
     
    steroid hormone receptor complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axonal growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP4
    Names
    FK506 binding protein 4, 59kDa
    HSP binding immunophilin
    T-cell FK506-binding protein, 59kD
    peptidylprolyl cis-trans isomerase
    rotamase
    NP_002005.1
    XP_011519231.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002014.3NP_002005.1  peptidyl-prolyl cis-trans isomerase FKBP4

      See identical proteins and their annotated locations for NP_002005.1

      Status: REVIEWED

      Source sequence(s)
      AK024694, BC001786, BQ083177, BQ446607, BU685040, DA392592
      Consensus CDS
      CCDS8512.1
      UniProtKB/Swiss-Prot
      Q02790
      Related
      ENSP00000001008.4, OTTHUMP00000115497, ENST00000001008.5, OTTHUMT00000206861
      Conserved Domains (4) summary
      sd00006
      Location:274301
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:43134
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      cl26002
      Location:250395
      TPR_11; TPR repeat
      cl27578
      Location:155254
      FKBP_N; Domain amino terminal to FKBP-type peptidyl-prolyl isomerase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      2794942..2805423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520929.2XP_011519231.1  peptidyl-prolyl cis-trans isomerase FKBP4 isoform X1

      Conserved Domains (6) summary
      TIGR03516
      Location:110209
      ppisom_GldI; peptidyl-prolyl isomerase, gliding motility-associated
      sd00006
      Location:229256
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:289
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam00515
      Location:276307
      TPR_1; Tetratricopeptide repeat
      pfam07719
      Location:309341
      TPR_2; Tetratricopeptide repeat
      pfam13414
      Location:277339
      TPR_11; TPR repeat
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