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    Zbtb7b zinc finger and BTB domain containing 7B [ Mus musculus (house mouse) ]

    Gene ID: 22724, updated on 26-Jun-2019

    Summary

    Official Symbol
    Zbtb7bprovided by MGI
    Official Full Name
    zinc finger and BTB domain containing 7Bprovided by MGI
    Primary source
    MGI:MGI:102755
    See related
    Ensembl:ENSMUSG00000028042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Thpok; Zfp67; c-Krox
    Expression
    Broad expression in colon adult (RPKM 66.4), duodenum adult (RPKM 59.2) and 18 other tissues See more
    Orthologs

    Genomic context

    See Zbtb7b in Genome Data Viewer
    Location:
    3 F1; 3 39.09 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (89377644..89394815, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (89181568..89197125, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 15 (metargidin) Neighboring gene DC-STAMP domain containing 1 Neighboring gene DC-STAMP domain containing 2 Neighboring gene predicted gene 15417 Neighboring gene lens epithelial protein Neighboring gene flavin adenine dinucleotide synthetase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC102577

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enhancer sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    NK T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adaptive thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-17 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lactation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of CD8-positive, alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of NK T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T-helper 17 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of CD4-positive, alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of SREBP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of histone deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of CD4-positive, alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of CD8-positive, alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription involved in cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to insulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 7B
    Names
    T-helper-inducing POZ/Krueppel-like factor
    Vzinc finger and BTB domain containing 7B
    krueppel-related zinc finger protein cKrox
    zinc finger protein 67
    zinc finger protein Th-POK

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355206.1NP_001342135.1  zinc finger and BTB domain-containing protein 7B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC171273, AK171443, CX220825
      Conserved Domains (4) summary
      COG5048
      Location:412491
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:443463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:87207
      BTB; BTB/POZ domain
      pfam13465
      Location:430452
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001355211.1NP_001342140.1  zinc finger and BTB domain-containing protein 7B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC171273, AK149976, CX220825
      Conserved Domains (4) summary
      COG5048
      Location:349428
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24144
      BTB; BTB/POZ domain
      pfam13465
      Location:420445
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001355212.1NP_001342141.1  zinc finger and BTB domain-containing protein 7B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC171273, AK155784, CX220825
      Conserved Domains (4) summary
      COG5048
      Location:349428
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24144
      BTB; BTB/POZ domain
      pfam13465
      Location:420445
      zf-H2C2_2; Zinc-finger double domain
    4. NM_009565.5NP_033591.2  zinc finger and BTB domain-containing protein 7B isoform 2

      See identical proteins and their annotated locations for NP_033591.2

      Status: VALIDATED

      Source sequence(s)
      AC171273, BC091651, CX220825
      Consensus CDS
      CCDS17504.1
      UniProtKB/Swiss-Prot
      Q64321
      UniProtKB/TrEMBL
      Q5BJ24
      Related
      ENSMUSP00000029677.8, ENSMUST00000029677.8
      Conserved Domains (4) summary
      COG5048
      Location:349428
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24144
      BTB; BTB/POZ domain
      pfam13465
      Location:420445
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      89377644..89394815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501317.3XP_006501380.1  zinc finger and BTB domain-containing protein 7B isoform X1

      See identical proteins and their annotated locations for XP_006501380.1

      UniProtKB/Swiss-Prot
      Q64321
      UniProtKB/TrEMBL
      Q5BJ24
      Conserved Domains (4) summary
      COG5048
      Location:349428
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24144
      BTB; BTB/POZ domain
      pfam13465
      Location:420445
      zf-H2C2_2; Zinc-finger double domain
    2. XM_006501314.2XP_006501377.1  zinc finger and BTB domain-containing protein 7B isoform X1

      See identical proteins and their annotated locations for XP_006501377.1

      UniProtKB/Swiss-Prot
      Q64321
      UniProtKB/TrEMBL
      Q5BJ24
      Conserved Domains (4) summary
      COG5048
      Location:349428
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24144
      BTB; BTB/POZ domain
      pfam13465
      Location:420445
      zf-H2C2_2; Zinc-finger double domain
    3. XM_006501313.2XP_006501376.1  zinc finger and BTB domain-containing protein 7B isoform X1

      See identical proteins and their annotated locations for XP_006501376.1

      UniProtKB/Swiss-Prot
      Q64321
      UniProtKB/TrEMBL
      Q5BJ24
      Conserved Domains (4) summary
      COG5048
      Location:349428
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24144
      BTB; BTB/POZ domain
      pfam13465
      Location:420445
      zf-H2C2_2; Zinc-finger double domain
    4. XM_006501316.2XP_006501379.1  zinc finger and BTB domain-containing protein 7B isoform X1

      See identical proteins and their annotated locations for XP_006501379.1

      UniProtKB/Swiss-Prot
      Q64321
      UniProtKB/TrEMBL
      Q5BJ24
      Conserved Domains (4) summary
      COG5048
      Location:349428
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24144
      BTB; BTB/POZ domain
      pfam13465
      Location:420445
      zf-H2C2_2; Zinc-finger double domain
    5. XM_006501319.3XP_006501382.1  zinc finger and BTB domain-containing protein 7B isoform X1

      UniProtKB/Swiss-Prot
      Q64321
      UniProtKB/TrEMBL
      Q5BJ24
      Related
      ENSMUSP00000103055.1, ENSMUST00000107432.7
      Conserved Domains (4) summary
      COG5048
      Location:349428
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24144
      BTB; BTB/POZ domain
      pfam13465
      Location:420445
      zf-H2C2_2; Zinc-finger double domain
    6. XM_006501318.3XP_006501381.1  zinc finger and BTB domain-containing protein 7B isoform X1

      UniProtKB/Swiss-Prot
      Q64321
      UniProtKB/TrEMBL
      Q5BJ24
      Related
      ENSMUSP00000103056.1, ENSMUST00000107433.7
      Conserved Domains (4) summary
      COG5048
      Location:349428
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24144
      BTB; BTB/POZ domain
      pfam13465
      Location:420445
      zf-H2C2_2; Zinc-finger double domain
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