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    Adm2 adrenomedullin 2 [ Mus musculus (house mouse) ]

    Gene ID: 223780, updated on 18-Sep-2018

    Summary

    Official Symbol
    Adm2provided by MGI
    Official Full Name
    adrenomedullin 2provided by MGI
    Primary source
    MGI:MGI:2675256
    See related
    Ensembl:ENSMUSG00000054136
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Am2; IMD; Imdn
    Summary
    This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. Intravenous injection of the active peptide was found to protect mouse lungs from ischemia/reperfusion injury. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in liver E18 (RPKM 5.7), kidney adult (RPKM 4.8) and 12 other tissues See more
    Orthologs

    Genomic context

    See Adm2 in Genome Data Viewer
    Location:
    15; 15 E3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (89322720..89324731)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (89153403..89155162)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6, regulatory subunit 2 Neighboring gene SET binding factor 1 Neighboring gene microRNA 6959 Neighboring gene myo-inositol oxygenase Neighboring gene lipase maturation factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    digestion ISO
    Inferred from Sequence Orthology
    more info
     
    feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182928.5NP_891558.1  ADM2 preproprotein

      See identical proteins and their annotated locations for NP_891558.1

      Status: REVIEWED

      Source sequence(s)
      BB705319, CJ052708, DV649647, DV661267
      Consensus CDS
      CCDS27744.1
      UniProtKB/Swiss-Prot
      Q7TNK8
      Related
      ENSMUSP00000064761.5, ENSMUST00000066991.6
      Conserved Domains (1) summary
      pfam00214
      Location:109150
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      89322720..89324731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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