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    HEPACAM hepatic and glial cell adhesion molecule [ Homo sapiens (human) ]

    Gene ID: 220296, updated on 28-May-2019

    Summary

    Official Symbol
    HEPACAMprovided by HGNC
    Official Full Name
    hepatic and glial cell adhesion moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:26361
    See related
    Ensembl:ENSG00000165478 MIM:611642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HEPN1; MLC2A; MLC2B; GlialCAM
    Summary
    The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011]
    Expression
    Biased expression in brain (RPKM 47.9), fat (RPKM 15.6) and 1 other tissue See more
    Orthologs

    Genomic context

    See HEPACAM in Genome Data Viewer
    Location:
    11q24.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (124919244..124936412, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124789089..124806308, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene roundabout guidance receptor 3 Neighboring gene uncharacterized LOC107984406 Neighboring gene roundabout guidance receptor 4 Neighboring gene hepatocellular carcinoma, down-regulated 1 Neighboring gene CCDC15 divergent transcript Neighboring gene coiled-coil domain containing 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ25530

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    hepatocyte cell adhesion molecule
    Names
    Putative cancer susceptibility gene HEPN1 protein
    protein hepaCAM

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029603.1 RefSeqGene

      Range
      5001..22164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_152722.5NP_689935.2  hepatocyte cell adhesion molecule precursor

      See identical proteins and their annotated locations for NP_689935.2

      Status: REVIEWED

      Source sequence(s)
      AP003501, AY047587, BC037810, BC113562, DA239226
      Consensus CDS
      CCDS8456.1
      UniProtKB/Swiss-Prot
      Q14CZ8
      Related
      ENSP00000298251.4, ENST00000298251.5
      Conserved Domains (3) summary
      smart00410
      Location:154235
      IG_like; Immunoglobulin like
      pfam07686
      Location:41141
      V-set; Immunoglobulin V-set domain
      pfam13895
      Location:150235
      Ig_2; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      124919244..124936412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271449.2XP_005271506.1  hepatocyte cell adhesion molecule isoform X2

      See identical proteins and their annotated locations for XP_005271506.1

      Conserved Domains (3) summary
      smart00410
      Location:154235
      IG_like; Immunoglobulin like
      pfam07686
      Location:41141
      V-set; Immunoglobulin V-set domain
      pfam13895
      Location:150235
      Ig_2; Immunoglobulin domain
    2. XM_017017361.1XP_016872850.1  hepatocyte cell adhesion molecule isoform X1

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