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    Tpp2 tripeptidyl peptidase II [ Mus musculus (house mouse) ]

    Gene ID: 22019, updated on 5-Aug-2018

    Summary

    Official Symbol
    Tpp2provided by MGI
    Official Full Name
    tripeptidyl peptidase IIprovided by MGI
    Primary source
    MGI:MGI:102724
    See related
    Ensembl:ENSMUSG00000041763 Vega:OTTMUSG00000046400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TPP-2; TppII
    Expression
    Ubiquitous expression in testis adult (RPKM 13.0), placenta adult (RPKM 12.4) and 27 other tissues See more
    Orthologs

    Genomic context

    See Tpp2 in Genome Data Viewer
    Location:
    1 C1.1; 1 23.5 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (43933865..44003000)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (43990852..44059816)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor 1 pseudogene Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 27 pseudogene Neighboring gene methyltransferase like 21C Neighboring gene coiled-coil domain containing 168

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tripeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tripeptidyl-peptidase 2
    Names
    TPP-II
    tripeptidyl aminopeptidase
    NP_001297469.1
    NP_033444.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310540.1NP_001297469.1  tripeptidyl-peptidase 2 isoform 2

      See identical proteins and their annotated locations for NP_001297469.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC060627, BY147762
      Consensus CDS
      CCDS78577.1
      UniProtKB/Swiss-Prot
      Q64514
      Related
      ENSMUSP00000139918.1, OTTMUSP00000066805, ENSMUST00000188313.6, OTTMUST00000120875
      Conserved Domains (3) summary
      cd04857
      Location:14489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:236500
      Peptidase_S8; Subtilase family
      pfam12580
      Location:777960
      TPPII; Tripeptidyl peptidase II
    2. NM_009418.3NP_033444.1  tripeptidyl-peptidase 2 isoform 1

      See identical proteins and their annotated locations for NP_033444.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BB725588, BC060627, BY147762
      Consensus CDS
      CCDS14926.1
      UniProtKB/Swiss-Prot
      Q64514
      Related
      ENSMUSP00000085244.3, OTTMUSP00000066804, ENSMUST00000087933.9, OTTMUST00000120872
      Conserved Domains (3) summary
      cd04857
      Location:14489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:236500
      Peptidase_S8; Subtilase family
      pfam12580
      Location:777960
      TPPII; Tripeptidyl peptidase II

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      43933865..44003000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_373249.3 RNA Sequence

    2. XR_001784011.1 RNA Sequence

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