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    Tesk1 testis specific protein kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 21754, updated on 19-Mar-2019

    Summary

    Official Symbol
    Tesk1provided by MGI
    Official Full Name
    testis specific protein kinase 1provided by MGI
    Primary source
    MGI:MGI:1201675
    See related
    Ensembl:ENSMUSG00000028458
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI326901
    Expression
    Biased expression in testis adult (RPKM 319.6), adrenal adult (RPKM 38.4) and 14 other tissues See more
    Orthologs

    Genomic context

    See Tesk1 in Genome Data Viewer
    Location:
    4; 4 A5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (43442277..43448075)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (43455149..43460947)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene ATPase, class I, type 8B, member 5 Neighboring gene predicted gene, 46850 Neighboring gene RUN and SH3 domain containing 2 Neighboring gene family with sequence similarity 166, member B Neighboring gene CD72 antigen Neighboring gene suppression inducing transmembrane adaptor 1 Neighboring gene RNA component of mitochondrial RNAase P

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity testis-specific protein kinase 1
    Names
    testicular protein kinase 1
    NP_035701.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011571.3NP_035701.3  dual specificity testis-specific protein kinase 1

      See identical proteins and their annotated locations for NP_035701.3

      Status: VALIDATED

      Source sequence(s)
      AK144302, BB325506, BC099699
      Consensus CDS
      CCDS18094.1
      UniProtKB/Swiss-Prot
      O70146
      Related
      ENSMUSP00000050087.6, ENSMUST00000060864.12
      Conserved Domains (2) summary
      smart00219
      Location:56306
      TyrKc; Tyrosine kinase, catalytic domain
      cd14155
      Location:58312
      PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      43442277..43448075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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