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    Engase endo-beta-N-acetylglucosaminidase [ Mus musculus (house mouse) ]

    Gene ID: 217364, updated on 23-May-2018

    Summary

    Official Symbol
    Engaseprovided by MGI
    Official Full Name
    endo-beta-N-acetylglucosaminidaseprovided by MGI
    Primary source
    MGI:MGI:2443788
    See related
    Ensembl:ENSMUSG00000033857 Vega:OTTMUSG00000003973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C130099A03; D230014K01Rik
    Expression
    Ubiquitous expression in colon adult (RPKM 10.6), thymus adult (RPKM 10.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Engase in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (118476066..118489209)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (118338274..118350512)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene C1q and tumor necrosis factor related protein 1 Neighboring gene predicted gene 11747 Neighboring gene ribosomal protein L18 pseudogene Neighboring gene RNA binding protein, fox-1 homolog (C. elegans) 3 Neighboring gene predicted gene 11750 Neighboring gene predicted gene, 35710

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein deglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein deglycosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytosolic endo-beta-N-acetylglucosaminidase
    NP_766161.1
    XP_006533193.1
    XP_006533194.1
    XP_006533195.1
    XP_006533196.1
    XP_017169987.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359368.1NP_001346297.1  cytosolic endo-beta-N-acetylglucosaminidase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK048667, BC060640, BY070749
      Conserved Domains (1) summary
      cd06547
      Location:27337
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
    2. NM_172573.3NP_766161.1  cytosolic endo-beta-N-acetylglucosaminidase isoform 1

      See identical proteins and their annotated locations for NP_766161.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK048667, BC060640, BY070749
      Consensus CDS
      CCDS25704.1
      UniProtKB/Swiss-Prot
      Q8BX80
      Related
      ENSMUSP00000117538.2, OTTMUSP00000004300, ENSMUST00000135383.8
      Conserved Domains (1) summary
      cd06547
      Location:118428
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

    RNA

    1. NR_153103.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses alternate splice sites in the 5' terminal exon, as well as in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK048667, AK084254, BC060640, BY070749

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      118476066..118489209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533130.3XP_006533193.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X1

      Conserved Domains (1) summary
      cd06547
      Location:194504
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
    2. XM_017314498.1XP_017169987.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X2

    3. XM_006533132.3XP_006533195.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X4

      Conserved Domains (1) summary
      cd06547
      Location:27337
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
    4. XM_006533133.3XP_006533196.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X5

      Related
      ENSMUSP00000125886.1, OTTMUSP00000051708, ENSMUST00000168689.1, OTTMUST00000093273
      Conserved Domains (1) summary
      cl10447
      Location:3123
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
    5. XM_006533131.3XP_006533194.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X3

      Conserved Domains (1) summary
      cd06547
      Location:27337
      GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
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