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    Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 20724, updated on 31-Jan-2019

    Summary

    Official Symbol
    Serpinb5provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B, member 5provided by MGI
    Primary source
    MGI:MGI:109579
    See related
    Ensembl:ENSMUSG00000067006
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PI-5; Spi7; Maspin; AI462524; AI646751; ovalbumin; 1110036M19Rik
    Expression
    Biased expression in bladder adult (RPKM 5.5), colon adult (RPKM 2.3) and 7 other tissues See more
    Orthologs

    Genomic context

    See Serpinb5 in Genome Data Viewer
    Location:
    1; 1 E2.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (106861180..106883348)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (108757757..108779925)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene 3-ketodihydrosphingosine reductase Neighboring gene vacuolar protein sorting 4B Neighboring gene POU domain, class 2, transcription factor 3, related sequence 1 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • p53 signaling, organism-specific biosystem (from WikiPathways)
      p53 signaling, organism-specific biosystemhttp://www.kegg.jp/ (mmu04115) p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcription...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    prostate gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    serpin B5
    Names
    peptidase inhibitor 5
    protease inhibitor 5
    serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
    serine (or cysteine) proteinase inhibitor, clade B, member 5
    serine protease inhibitor 7

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360853.1NP_001347782.1  serpin B5 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC025047, AC163626, AK136532, U54705
      Conserved Domains (1) summary
      cd02057
      Location:4375
      maspin_like; Maspin (mammary serine proteinase inhibitor), a member of the serpin superfamily, with a multitude of effects on cells and tissues at an assortment of developmental stages. Maspin has tumor suppressing activity against breast and prostate cancer. In ...
    2. NM_001360854.1NP_001347783.1  serpin B5 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC025047, AC163626
      Conserved Domains (1) summary
      cl00137
      Location:1204
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    3. NM_009257.4NP_033283.1  serpin B5 isoform a

      See identical proteins and their annotated locations for NP_033283.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC025047, AC163626, AK136532
      Consensus CDS
      CCDS35684.1
      UniProtKB/Swiss-Prot
      P70124
      Related
      ENSMUSP00000083908.6, ENSMUST00000086701.12
      Conserved Domains (1) summary
      cd02057
      Location:4375
      maspin_like; Maspin (mammary serine proteinase inhibitor), a member of the serpin superfamily, with a multitude of effects on cells and tissues at an assortment of developmental stages. Maspin has tumor suppressing activity against breast and prostate cancer. In ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      106861180..106883348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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