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    Snap23 synaptosomal-associated protein 23 [ Mus musculus (house mouse) ]

    Gene ID: 20619, updated on 18-Sep-2018

    Summary

    Official Symbol
    Snap23provided by MGI
    Official Full Name
    synaptosomal-associated protein 23provided by MGI
    Primary source
    MGI:MGI:109356
    See related
    Ensembl:ENSMUSG00000027287 Vega:OTTMUSG00000015619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sndt; 23kDa; Syndet; SNAP-23; AA408749
    Expression
    Broad expression in placenta adult (RPKM 10.3), bladder adult (RPKM 8.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See Snap23 in Genome Data Viewer
    Location:
    2 60.37 cM; 2 E5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (120567653..120601255)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (120393407..120426458)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931402G19 gene Neighboring gene calpain 3 Neighboring gene zinc finger protein 106 Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin-like complex, subunit 2 Neighboring gene START domain containing 9 Neighboring gene kinesin family member 16B pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SNAP receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    exocytic insertion of neurotransmitter receptor to postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histamine secretion by mast cell ISO
    Inferred from Sequence Orthology
    more info
     
    membrane fusion ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle-mediated transport in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SNARE complex ISO
    Inferred from Sequence Orthology
    more info
     
    azurophil granule ISO
    Inferred from Sequence Orthology
    more info
     
    cell ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    specific granule ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    synaptosomal-associated protein 23
    Names
    synaptosomal-associated protein, 23kD
    vesicle-membrane fusion protein SNAP-23

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177792.1NP_001171263.1  synaptosomal-associated protein 23 isoform a

      See identical proteins and their annotated locations for NP_001171263.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform a).
      Source sequence(s)
      AK017311, AK019162
      Consensus CDS
      CCDS50681.1
      UniProtKB/Swiss-Prot
      O09044
      UniProtKB/TrEMBL
      Q9D3L3
      Related
      ENSMUSP00000112138.1, OTTMUSP00000016634, ENSMUST00000116437.7, OTTMUST00000037102
      Conserved Domains (3) summary
      cd15884
      Location:159217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100157
      SNAP-25; SNAP-25 family
    2. NM_001177793.1NP_001171264.1  synaptosomal-associated protein 23 isoform b

      See identical proteins and their annotated locations for NP_001171264.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the 5' UTR and lacks an alternate, in-frame, coding exon, compared to variant 1. Variants 2 and 3 encode the same protein (isoform b).
      Source sequence(s)
      AK019162, BC070456
      Consensus CDS
      CCDS16622.1
      UniProtKB/Swiss-Prot
      O09044
      UniProtKB/TrEMBL
      A2AKH4
      Related
      ENSMUSP00000028743.3, OTTMUSP00000016635, ENSMUST00000028743.9, OTTMUST00000037103
      Conserved Domains (3) summary
      cd15884
      Location:148206
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86146
      SNAP-25; SNAP-25 family
    3. NM_009222.3NP_033248.1  synaptosomal-associated protein 23 isoform b

      See identical proteins and their annotated locations for NP_033248.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame, exon, compared to variant 1. Variants 2 and 3 encode the same protein (isoform b).
      Source sequence(s)
      AK019162
      Consensus CDS
      CCDS16622.1
      UniProtKB/Swiss-Prot
      O09044
      UniProtKB/TrEMBL
      A2AKH4
      Related
      ENSMUSP00000106339.2, OTTMUSP00000016633, ENSMUST00000110711.8, OTTMUST00000037101
      Conserved Domains (3) summary
      cd15884
      Location:148206
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86146
      SNAP-25; SNAP-25 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      120567653..120601255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499055.3XP_006499118.1  synaptosomal-associated protein 23 isoform X1

      See identical proteins and their annotated locations for XP_006499118.1

      UniProtKB/TrEMBL
      Q9D3L3
      Conserved Domains (3) summary
      cd15884
      Location:159217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100157
      SNAP-25; SNAP-25 family
    2. XM_006499054.3XP_006499117.1  synaptosomal-associated protein 23 isoform X1

      See identical proteins and their annotated locations for XP_006499117.1

      UniProtKB/TrEMBL
      Q9D3L3
      Conserved Domains (3) summary
      cd15884
      Location:159217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100157
      SNAP-25; SNAP-25 family
    3. XM_006499056.3XP_006499119.1  synaptosomal-associated protein 23 isoform X1

      See identical proteins and their annotated locations for XP_006499119.1

      UniProtKB/TrEMBL
      Q9D3L3
      Conserved Domains (3) summary
      cd15884
      Location:159217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100157
      SNAP-25; SNAP-25 family
    4. XM_006499057.3XP_006499120.1  synaptosomal-associated protein 23 isoform X2

      See identical proteins and their annotated locations for XP_006499120.1

      UniProtKB/Swiss-Prot
      O09044
      UniProtKB/TrEMBL
      A2AKH4
      Conserved Domains (3) summary
      cd15884
      Location:148206
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86146
      SNAP-25; SNAP-25 family
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