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    Slc22a3 solute carrier family 22 (organic cation transporter), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 20519, updated on 8-Oct-2018

    Summary

    Official Symbol
    Slc22a3provided by MGI
    Official Full Name
    solute carrier family 22 (organic cation transporter), member 3provided by MGI
    Primary source
    MGI:MGI:1333817
    See related
    Ensembl:ENSMUSG00000023828
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EMT; Oct3; Orct3; Slca22a3
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 16.2), genital fat pad adult (RPKM 10.1) and 10 other tissues See more
    Orthologs

    Genomic context

    See Slc22a3 in Genome Data Viewer
    Location:
    17 A1; 17 8.52 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (12419972..12507704, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (12612838..12700570, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41527 Neighboring gene plasminogen Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene RIKEN cDNA C030013G03 gene Neighboring gene solute carrier family 22 (organic cation transporter), member 2 Neighboring gene solute carrier family 22 (organic cation transporter), member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    dopamine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    organic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    quaternary ammonium group transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    quaternary ammonium group transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    toxin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    dopamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    histamine transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histamine uptake IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    monoamine transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    organic cation transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organic cation transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    quaternary ammonium group transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    quaternary ammonium group transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of appetite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    solute carrier family 22 member 3
    Names
    organic cation transporter 3
    solute carrier family 22, member 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011395.2NP_035525.1  solute carrier family 22 member 3

      See identical proteins and their annotated locations for NP_035525.1

      Status: PROVISIONAL

      Source sequence(s)
      AC087901, AC132106
      Consensus CDS
      CCDS28391.1
      UniProtKB/Swiss-Prot
      Q9WTW5
      UniProtKB/TrEMBL
      Q547K2
      Related
      ENSMUSP00000024595.2, ENSMUST00000024595.3
      Conserved Domains (2) summary
      cd06174
      Location:145513
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:12523
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      12419972..12507704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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