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    EPHB2 EPH receptor B2 [ Homo sapiens (human) ]

    Gene ID: 2048, updated on 12-Aug-2018

    Summary

    Official Symbol
    EPHB2provided by HGNC
    Official Full Name
    EPH receptor B2provided by HGNC
    Primary source
    HGNC:HGNC:3393
    See related
    Ensembl:ENSG00000133216 MIM:600997; Vega:OTTHUMG00000002881
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5
    Summary
    This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
    Expression
    Broad expression in colon (RPKM 7.3), small intestine (RPKM 5.2) and 17 other tissues See more
    Orthologs

    Genomic context

    See EPHB2 in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (22710770..22921500)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23037263..23241823)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene complement C1q C chain Neighboring gene complement C1q B chain Neighboring gene microRNA 4684 Neighboring gene microRNA 4253 Neighboring gene lactamase beta like 1 Neighboring gene testis expressed 46

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of EPH receptor B2 (EPHB2) in peptide-treated PBMCs PubMed
    Nef nef HIV-1 Nef rapidly terminates ERK activation in the presence of TPA in a macrophage-inducing system PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
      EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
    • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
      EPH-ephrin mediated repulsion of cells, organism-specific biosystemDespite high-affinity multimeric interaction between EPHs and ephrins (EFNs), the cellular response to EPH-EFN engagement is usually repulsion between the two cells and signal termination. These repu...
    • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHB forward signaling, organism-specific biosystem
      EPHB forward signaling
    • EPHB-mediated forward signaling, organism-specific biosystem (from REACTOME)
      EPHB-mediated forward signaling, organism-specific biosystemMultiple EPHB receptors contribute directly to dendritic spine development and morphogenesis. These are more broadly involved in post-synaptic development through activation of focal adhesion kinase ...
    • Ephrin B reverse signaling, organism-specific biosystem (from Pathway Interaction Database)
      Ephrin B reverse signaling, organism-specific biosystem
      Ephrin B reverse signaling
    • Ephrin signaling, organism-specific biosystem (from REACTOME)
      Ephrin signaling, organism-specific biosystemThe interaction between ephrin (EFN) ligands and EPH receptors results not only in forward signaling through the EPH receptor, but also in 'reverse' signaling through the EFN ligand itself. Reverse s...
    • EphrinB-EPHB pathway, organism-specific biosystem (from Pathway Interaction Database)
      EphrinB-EPHB pathway, organism-specific biosystem
      EphrinB-EPHB pathway
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • MAP kinase cascade, organism-specific biosystem (from BIOCYC)
      MAP kinase cascade, organism-specific biosystemThe MAP kinase cascade describes a sequence of phosphorylation events involving serine/threonine-specific protein kinases. Used by various signal transduction pathways, this cascade constitutes a com...
    • NLR Proteins, organism-specific biosystem (from WikiPathways)
      NLR Proteins, organism-specific biosystemMammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen associated-molecular-patterns (PAMPs...
    • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-2-mediated signaling events, organism-specific biosystem
      Syndecan-2-mediated signaling events
    • Transcriptional activation by NRF2, organism-specific biosystem (from WikiPathways)
      Transcriptional activation by NRF2, organism-specific biosystemBased on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4]. Nrf2 induces the expression of many antioxidant enzymes. It is therefore thought to be involved in ox...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC87492

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    amyloid-beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon guidance receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein-containing complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane-ephrin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transmembrane-ephrin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axonal fasciculation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    camera-type eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    central nervous system projection neuron axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    commissural neuron axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    corpus callosum development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    inactivation of MAPKK activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    inner ear morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    learning or memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of NMDA glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron projection retraction IEA
    Inferred from Electronic Annotation
    more info
     
    optic nerve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of NMDA glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of long-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of long-term synaptic potentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    postsynaptic membrane assembly IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of body fluid levels ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of neuronal synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    retinal ganglion cell axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    roof of mouth development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    urogenital system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynapse TAS
    Traceable Author Statement
    more info
    PubMed 
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ephrin type-B receptor 2
    Names
    EPH-like kinase 5
    developmentally-regulated Eph-related tyrosine kinase
    elk-related tyrosine kinase
    eph tyrosine kinase 3
    protein-tyrosine kinase HEK5
    renal carcinoma antigen NY-REN-47
    tyrosine-protein kinase TYRO5
    tyrosine-protein kinase receptor EPH-3
    NP_001296121.1
    NP_001296122.1
    NP_004433.2
    NP_059145.2
    XP_006710504.1
    XP_006710505.1
    XP_024309663.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011804.2 RefSeqGene

      Range
      5001..215663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_780

    mRNA and Protein(s)

    1. NM_001309192.1NP_001296121.1  ephrin type-B receptor 2 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region compared to variant 2. It encodes isoform 3, which is shorter than isoform 2.
      Source sequence(s)
      AB210018, AK025975, AK125423, AK299701, AL035704, BC007903, BC018763, BC067861, CA417154, DB282024
      UniProtKB/TrEMBL
      B4DSE0, Q4LE53, Q6NVW1
      Conserved Domains (7) summary
      cd05065
      Location:558826
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:852922
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:852919
      SAM; Sterile alpha motif
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:437520
      fn3; Fibronectin type III domain
      pfam07714
      Location:563822
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:519558
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    2. NM_001309193.1NP_001296122.1  ephrin type-B receptor 2 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001296122.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site at an internal exon and alternate splice sites in the 3' coding region and 3' UTR, which results in a longer and novel 3' coding region compared to variant 2. It encodes isoform 4, which is longer than and has a distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AB210018, AF025304, AK025975, AK125423, AL035704, BC067861, CA417154, DB282024
      Consensus CDS
      CCDS81279.1
      UniProtKB/Swiss-Prot
      P29323
      UniProtKB/TrEMBL
      Q4LE53, Q6NVW1
      Related
      ENSP00000383053.3, OTTHUMP00000002915, ENST00000400191.7, OTTHUMT00000008060
      Conserved Domains (7) summary
      cd05065
      Location:616884
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:910980
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:910977
      SAM; Sterile alpha motif
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:437520
      fn3; Fibronectin type III domain
      pfam07714
      Location:621880
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:548616
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    3. NM_004442.7NP_004433.2  ephrin type-B receptor 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_004433.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. It encodes isoform 2.
      Source sequence(s)
      AK025975, AL035704, BC067861, DB282024, L41939
      Consensus CDS
      CCDS230.1
      UniProtKB/Swiss-Prot
      P29323
      UniProtKB/TrEMBL
      Q6NVW1
      Related
      ENSP00000363763.3, OTTHUMP00000002916, ENST00000374632.7, OTTHUMT00000008061
      Conserved Domains (7) summary
      cd05065
      Location:617885
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:911981
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:911978
      SAM; Sterile alpha motif
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:437520
      fn3; Fibronectin type III domain
      pfam07714
      Location:622881
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:548617
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    4. NM_017449.4NP_059145.2  ephrin type-B receptor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_059145.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site compared to variant 2. It encodes isoform 1, which is shorter than isoform 2.
      Source sequence(s)
      AB210018, AF025304, AK025975, AK125423, AL035704, BC067861, CA417154, DB282024
      Consensus CDS
      CCDS229.2
      UniProtKB/Swiss-Prot
      P29323
      UniProtKB/TrEMBL
      Q4LE53, Q6NVW1
      Related
      ENSP00000363761.3, OTTHUMP00000002914, ENST00000374630.7, OTTHUMT00000008059
      Conserved Domains (7) summary
      cd05065
      Location:616884
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:910980
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:910977
      SAM; Sterile alpha motif
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:437520
      fn3; Fibronectin type III domain
      pfam07714
      Location:621880
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:548616
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      22710770..22921500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006710442.4XP_006710505.1  ephrin type-B receptor 2 isoform X2

      Conserved Domains (7) summary
      cd05065
      Location:586854
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:880950
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:880947
      SAM; Sterile alpha motif
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:326421
      fn3; Fibronectin type III domain
      pfam07714
      Location:591850
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:517586
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    2. XM_006710441.4XP_006710504.1  ephrin type-B receptor 2 isoform X1

      Related
      ENSP00000363758.1, ENST00000374627.1
      Conserved Domains (7) summary
      cd05065
      Location:610878
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:904974
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      smart00454
      Location:904971
      SAM; Sterile alpha motif
      cd10477
      Location:12189
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:430513
      fn3; Fibronectin type III domain
      pfam07714
      Location:615874
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:541610
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    3. XM_024453895.1XP_024309663.1  ephrin type-B receptor 2 isoform X3

      Conserved Domains (4) summary
      cd05065
      Location:175443
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:469539
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      pfam00041
      Location:179
      fn3; Fibronectin type III domain
      pfam14575
      Location:107175
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
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