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    EPHA8 EPH receptor A8 [ Homo sapiens (human) ]

    Gene ID: 2046, updated on 3-Jun-2018
    Official Symbol
    EPHA8provided by HGNC
    Official Full Name
    EPH receptor A8provided by HGNC
    Primary source
    HGNC:HGNC:3391
    See related
    Ensembl:ENSG00000070886 MIM:176945; Vega:OTTHUMG00000002892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EEK; EK3; HEK3
    Summary
    This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    See EPHA8 in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (22563502..22603594)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (22890004..22930087)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376856 Neighboring gene zinc finger and BTB domain containing 40 Neighboring gene microRNA 6127 Neighboring gene complement C1q A chain

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
      EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
    • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
      EPH-ephrin mediated repulsion of cells, organism-specific biosystemDespite high-affinity multimeric interaction between EPHs and ephrins (EFNs), the cellular response to EPH-EFN engagement is usually repulsion between the two cells and signal termination. These repu...
    • EPHA forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHA forward signaling, organism-specific biosystem
      EPHA forward signaling
    • EPHA-mediated growth cone collapse, organism-specific biosystem (from REACTOME)
      EPHA-mediated growth cone collapse, organism-specific biosystemEPH/Ephrin signaling is coupled to Rho family GTPases such as Rac, Rho and Cdc42 that connect bidirectional receptor-ligand interactions to changes in the actin cytoskeleton (Noren & Pasquale 2004, G...
    • EphrinA-EPHA pathway, organism-specific biosystem (from Pathway Interaction Database)
      EphrinA-EPHA pathway, organism-specific biosystem
      EphrinA-EPHA pathway
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA1459

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GPI-linked ephrin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitogen-activated protein kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to follicle-stimulating hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    substrate-dependent cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Preferred Names
    ephrin type-A receptor 8
    Names
    EPH- and ELK-related kinase
    EPH- and ELK-related tyrosine kinase
    EPH-like kinase 3
    hydroxyaryl-protein kinase
    protein-tyrosine kinase
    tyrosine-protein kinase receptor EEK
    tyrosylprotein kinase
    NP_001006944.1
    NP_065387.1
    XP_011539271.1
    XP_011539272.1
    XP_011539274.1
    XP_011539275.1
    XP_011539277.1
    XP_024309660.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006943.2NP_001006944.1  ephrin type-A receptor 8 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001006944.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1. This transcript is supported by mRNA transcripts but the predicted ORF and its predicted precursor sequence have not yet been experimentally confirmed.
      Source sequence(s)
      BC072417, DR007053
      Consensus CDS
      CCDS30626.1
      UniProtKB/Swiss-Prot
      P29322
      Related
      ENSP00000363775.4, OTTHUMP00000002935, ENST00000374644.8, OTTHUMT00000008086
      Conserved Domains (2) summary
      pfam00041
      Location:330418
      fn3; Fibronectin type III domain
      cl02704
      Location:31203
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    2. NM_020526.4NP_065387.1  ephrin type-A receptor 8 isoform 1 precursor

      See identical proteins and their annotated locations for NP_065387.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB040892, AL035703, BC072417, DR007053
      Consensus CDS
      CCDS225.1
      UniProtKB/Swiss-Prot
      P29322
      Related
      ENSP00000166244.3, OTTHUMP00000002934, ENST00000166244.7, OTTHUMT00000008085
      Conserved Domains (8) summary
      cd09550
      Location:933995
      SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
      smart00454
      Location:934994
      SAM; Sterile alpha motif
      cd00063
      Location:440531
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:630896
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:330423
      fn3; Fibronectin type III domain
      pfam07714
      Location:635892
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:566630
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:31203
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      22563502..22603594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540969.1XP_011539271.1  ephrin type-A receptor 8 isoform X1

      See identical proteins and their annotated locations for XP_011539271.1

      Conserved Domains (8) summary
      cd09550
      Location:858920
      SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
      smart00454
      Location:859919
      SAM; Sterile alpha motif
      cd00063
      Location:365456
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:555821
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:255348
      fn3; Fibronectin type III domain
      pfam07714
      Location:560817
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:491555
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1128
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    2. XM_011540972.1XP_011539274.1  ephrin type-A receptor 8 isoform X1

      See identical proteins and their annotated locations for XP_011539274.1

      Conserved Domains (8) summary
      cd09550
      Location:858920
      SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
      smart00454
      Location:859919
      SAM; Sterile alpha motif
      cd00063
      Location:365456
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:555821
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:255348
      fn3; Fibronectin type III domain
      pfam07714
      Location:560817
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:491555
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1128
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    3. XM_011540970.1XP_011539272.1  ephrin type-A receptor 8 isoform X1

      See identical proteins and their annotated locations for XP_011539272.1

      Conserved Domains (8) summary
      cd09550
      Location:858920
      SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
      smart00454
      Location:859919
      SAM; Sterile alpha motif
      cd00063
      Location:365456
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:555821
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:255348
      fn3; Fibronectin type III domain
      pfam07714
      Location:560817
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:491555
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1128
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    4. XM_011540973.1XP_011539275.1  ephrin type-A receptor 8 isoform X1

      See identical proteins and their annotated locations for XP_011539275.1

      Conserved Domains (8) summary
      cd09550
      Location:858920
      SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
      smart00454
      Location:859919
      SAM; Sterile alpha motif
      cd00063
      Location:365456
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:555821
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:255348
      fn3; Fibronectin type III domain
      pfam07714
      Location:560817
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:491555
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1128
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    5. XM_024453892.1XP_024309660.1  ephrin type-A receptor 8 isoform X2

      Conserved Domains (4) summary
      cd09550
      Location:528590
      SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
      cd05066
      Location:225491
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:34119
      fn3; Fibronectin type III domain
      pfam14575
      Location:161225
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    6. XM_011540975.3XP_011539277.1  ephrin type-A receptor 8 isoform X2

      Conserved Domains (4) summary
      cd09550
      Location:528590
      SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
      cd05066
      Location:225491
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:34119
      fn3; Fibronectin type III domain
      pfam14575
      Location:161225
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RNA

    1. XR_946576.2 RNA Sequence

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