Format

Send to:

Choose Destination
    • Showing Current items.

    CTTN cortactin [ Homo sapiens (human) ]

    Gene ID: 2017, updated on 8-Jul-2018
    Official Symbol
    CTTNprovided by HGNC
    Official Full Name
    cortactinprovided by HGNC
    Primary source
    HGNC:HGNC:3338
    See related
    Ensembl:ENSG00000085733 MIM:164765; Vega:OTTHUMG00000134307
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EMS1
    Summary
    This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in gall bladder (RPKM 41.5), adrenal (RPKM 38.4) and 25 other tissues See more
    Orthologs
    See CTTN in Genome Data Viewer
    Location:
    11q13.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (70398506..70436584)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (70244612..70282690)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369373 Neighboring gene PTPRF interacting protein alpha 1 Neighboring gene uncharacterized LOC107984347 Neighboring gene SH3 and multiple ankyrin repeat domains 2 Neighboring gene SHANK2 antisense RNA 1 Neighboring gene SHANK2 antisense RNA 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated cortactin (CTTN) protein is incorporated into HIV-1 Gag virus-like particles PubMed

    Go to the HIV-1, Human Interaction Database

    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
    • E-cadherin signaling in the nascent adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      E-cadherin signaling in the nascent adherens junction, organism-specific biosystem
      E-cadherin signaling in the nascent adherens junction
    • FGF signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FGF signaling pathway, organism-specific biosystem
      FGF signaling pathway
    • Hepatitis C and Hepatocellular Carcinoma, organism-specific biosystem (from WikiPathways)
      Hepatitis C and Hepatocellular Carcinoma, organism-specific biosystemPathway model based on hub miRNAs and their putative targets from network analysis. - From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carc...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • N-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
      N-cadherin signaling events, organism-specific biosystem
      N-cadherin signaling events
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
      Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
      Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from WikiPathways)
      Pathogenic Escherichia coli infection, organism-specific biosystemSources: [http://www.genome.jp/kegg/pathway/hsa/hsa05130.html KEGG]
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases activate PAKs, organism-specific biosystem (from REACTOME)
      RHO GTPases activate PAKs, organism-specific biosystemThe PAKs (p21-activated kinases) are a family of serine/threonine kinases mainly implicated in cytoskeletal rearrangements. All PAKs share a conserved catalytic domain located at the carboxyl terminu...
    • Shigellosis, organism-specific biosystem (from KEGG)
      Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Syndecan-3-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-3-mediated signaling events, organism-specific biosystem
      Syndecan-3-mediated signaling events
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ34459

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding HDA PubMed 
    profilin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton reorganization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic spine maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lamellipodium organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane organization TAS
    Traceable Author Statement
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of autophagy of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    substrate-dependent cell migration, cell extension IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    clathrin-coated pit ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion HDA PubMed 
    colocalizes_with growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic spindle midzone IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    podosome IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    src substrate cortactin
    Names
    1110020L01Rik
    amplaxin
    ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
    oncogene EMS1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029881.1 RefSeqGene

      Range
      5001..43079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184740.1NP_001171669.1  src substrate cortactin isoform c

      See identical proteins and their annotated locations for NP_001171669.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses different splice sites in the 3' coding region, which changes reading frame and the termination stop codon, compared to variant 1. The resulting protein (isoform c) has a longer and distinct C-terminus when it is compared to isoform a.
      Source sequence(s)
      AA325227, BC008799, BC033889, DA716772
      Consensus CDS
      CCDS53676.1
      UniProtKB/Swiss-Prot
      Q14247
      Related
      ENSP00000365745.3, OTTHUMP00000235667, ENST00000376561.7, OTTHUMT00000394097
      Conserved Domains (3) summary
      pfam02218
      Location:231266
      HS1_rep; Repeat in HS1/Cortactin
      cl05005
      Location:288363
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl17036
      Location:459501
      SH3; Src Homology 3 domain superfamily
    2. NM_005231.3NP_005222.2  src substrate cortactin isoform a

      See identical proteins and their annotated locations for NP_005222.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longest transcript.
      Source sequence(s)
      AK222613, AK291097, BC008799, DA716772
      Consensus CDS
      CCDS41680.1
      UniProtKB/Swiss-Prot
      Q14247
      UniProtKB/TrEMBL
      Q53HG7
      Related
      ENSP00000301843.8, OTTHUMP00000165962, ENST00000301843.12, OTTHUMT00000259233
      Conserved Domains (3) summary
      cd11959
      Location:496548
      SH3_Cortactin; Src homology 3 domain of Cortactin
      pfam02218
      Location:231266
      HS1_rep; Repeat in HS1/Cortactin
      cl05005
      Location:325400
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    3. NM_138565.2NP_612632.1  src substrate cortactin isoform b

      See identical proteins and their annotated locations for NP_612632.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal segment of sequence, compared to variant 1. The resulting protein (isoform b) has the same N- and C- termini but is shorter when it is compared to isoform a.
      Source sequence(s)
      AK222613, BC008799, DA716772
      Consensus CDS
      CCDS8197.1
      UniProtKB/Swiss-Prot
      Q14247
      UniProtKB/TrEMBL
      A0A024R5M3, Q53HG7
      Related
      ENSP00000317189.4, OTTHUMP00000165961, ENST00000346329.7, OTTHUMT00000259232
      Conserved Domains (4) summary
      cd11959
      Location:459511
      SH3_Cortactin; Src homology 3 domain of Cortactin
      pfam02218
      Location:231266
      HS1_rep; Repeat in HS1/Cortactin
      pfam15927
      Location:322359
      Casc1_N; Cancer susceptibility candidate 1 N-terminus
      cl26557
      Location:310445
      RNase_E_G; Ribonuclease E/G family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      70398506..70436584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006718447.3XP_006718510.1  src substrate cortactin isoform X1

      Conserved Domains (3) summary
      cd11959
      Location:422474
      SH3_Cortactin; Src homology 3 domain of Cortactin
      pfam02218
      Location:157192
      HS1_rep; Repeat in HS1/Cortactin
      cl05005
      Location:251326
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    2. XM_006718448.4XP_006718511.1  src substrate cortactin isoform X2

      Conserved Domains (1) summary
      pfam02218
      Location:231266
      HS1_rep; Repeat in HS1/Cortactin
    3. XM_017017312.2XP_016872801.1  src substrate cortactin isoform X3

    Support Center