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    MARK2 microtubule affinity regulating kinase 2 [ Homo sapiens (human) ]

    Gene ID: 2011, updated on 12-Aug-2018

    Summary

    Official Symbol
    MARK2provided by HGNC
    Official Full Name
    microtubule affinity regulating kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:3332
    See related
    Ensembl:ENSG00000072518 MIM:600526; Vega:OTTHUMG00000160504
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EMK1; EMK-1; PAR-1; Par1b; Par-1b
    Summary
    This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
    Expression
    Ubiquitous expression in esophagus (RPKM 11.9), colon (RPKM 10.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See MARK2 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (63838928..63911020)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63606400..63678492)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene spindlin interactor and repressor of chromatin binding Neighboring gene ATP synthase membrane subunit g pseudogene 1 Neighboring gene RNA, U6 small nuclear 1306, pseudogene Neighboring gene transfer RNA-Arg (CCT) 9-1 Neighboring gene REST corepressor 2 Neighboring gene N(alpha)-acetyltransferase 40, NatD catalytic subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC99619

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding HDA PubMed 
    cadherin binding HDA PubMed 
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    tau protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    tau-protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tau-protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tau-protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    activation of protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    autophagy of mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    axon development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    establishment of cell polarity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    establishment of cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    establishment or maintenance of cell polarity regulating cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    establishment or maintenance of epithelial cell apical/basal polarity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion localization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    peptidyl-threonine phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule bundle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase MARK2
    Names
    ELKL motif kinase 1
    MAP/microtubule affinity-regulating kinase 2
    PAR1 homolog b
    Ser/Thr protein kinase PAR-1B
    serine/threonine protein kinase EMK
    testicular tissue protein Li 117
    NP_001034558.2
    NP_001156768.1
    NP_001156769.1
    NP_004945.4
    NP_059672.2
    XP_011543091.1
    XP_011543092.1
    XP_011543093.1
    XP_011543094.1
    XP_011543095.1
    XP_011543096.1
    XP_011543097.1
    XP_011543098.1
    XP_011543099.1
    XP_011543100.1
    XP_016872799.1
    XP_016872800.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029771.1 RefSeqGene

      Range
      5001..77093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001039469.2NP_001034558.2  serine/threonine-protein kinase MARK2 isoform d

      See identical proteins and their annotated locations for NP_001034558.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
      Source sequence(s)
      AB188493, AK225766, AP003780, BC008771, BM719402
      Consensus CDS
      CCDS53649.1
      UniProtKB/Swiss-Prot
      Q7KZI7
      Related
      ENSP00000385751.2, ENST00000402010.6
      Conserved Domains (3) summary
      cd12201
      Location:689787
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      cd14406
      Location:322363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. NM_001163296.1NP_001156768.1  serine/threonine-protein kinase MARK2 isoform e

      See identical proteins and their annotated locations for NP_001156768.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 3' coding region, compared to variant 4. The resulting isoform (e) lacks two internal segments, compared to isoform d.
      Source sequence(s)
      AB188493, AK225766, AP003780, BM719402
      Consensus CDS
      CCDS53650.1
      UniProtKB/Swiss-Prot
      Q7KZI7
      UniProtKB/TrEMBL
      A0A140VJP1
      Related
      ENSP00000355091.5, OTTHUMP00000236749, ENST00000361128.9, OTTHUMT00000396087
      Conserved Domains (3) summary
      cd12201
      Location:620718
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      cd14406
      Location:322363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. NM_001163297.1NP_001156769.1  serine/threonine-protein kinase MARK2 isoform f

      See identical proteins and their annotated locations for NP_001156769.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks three alternate in-frame exons and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (f) lacks two internal segments and 1 internal residue, compared to isoform d.
      Source sequence(s)
      AB188493, AK225766, AP003780, BM719402
      Consensus CDS
      CCDS53651.1
      UniProtKB/Swiss-Prot
      Q7KZI7
      Related
      ENSP00000294247.9, OTTHUMP00000236750, ENST00000350490.11, OTTHUMT00000396088
      Conserved Domains (3) summary
      cd12201
      Location:610708
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      cd14406
      Location:322363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. NM_004954.4NP_004945.4  serine/threonine-protein kinase MARK2 isoform c

      See identical proteins and their annotated locations for NP_004945.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (c) lacks two internal segments and 1 internal residue, compared to isoform d.
      Source sequence(s)
      AB188493, AK225766, AP003780, BC084540, BM719402
      Consensus CDS
      CCDS8051.2
      UniProtKB/Swiss-Prot
      Q7KZI7
      Related
      ENSP00000425765.1, OTTHUMP00000218338, ENST00000508192.5, OTTHUMT00000360860
      Conserved Domains (3) summary
      cd12201
      Location:625723
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      cd14406
      Location:322363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. NM_017490.3NP_059672.2  serine/threonine-protein kinase MARK2 isoform a

      See identical proteins and their annotated locations for NP_059672.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, lacks an in-frame exon, and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (a) has a shorter N-terminus and lacks an internal segment and 1 internal residue, compared to isoform d.
      Source sequence(s)
      AK290339, AP003780, BM719402, BT007342, DA855402
      Consensus CDS
      CCDS41665.1
      UniProtKB/Swiss-Prot
      Q7KZI7
      UniProtKB/TrEMBL
      A8K2S4
      Related
      ENSP00000423974.2, OTTHUMP00000218340, ENST00000509502.6, OTTHUMT00000360862
      Conserved Domains (3) summary
      cd12201
      Location:646744
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      cd14406
      Location:289330
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:19271
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      63838928..63911020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017310.1XP_016872799.1  serine/threonine-protein kinase MARK2 isoform X6

      Related
      ENSP00000423452.3, OTTHUMP00000218339, ENST00000502399.7, OTTHUMT00000360861
    2. XM_011544789.1XP_011543091.1  serine/threonine-protein kinase MARK2 isoform X1

      Conserved Domains (4) summary
      cd12201
      Location:709807
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. XM_011544792.1XP_011543094.1  serine/threonine-protein kinase MARK2 isoform X4

      Conserved Domains (4) summary
      cd12201
      Location:694792
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. XM_011544790.1XP_011543092.1  serine/threonine-protein kinase MARK2 isoform X2

      Conserved Domains (4) summary
      cd12201
      Location:700798
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. XM_011544793.1XP_011543095.1  serine/threonine-protein kinase MARK2 isoform X5

      Conserved Domains (4) summary
      cd12201
      Location:685783
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    6. XM_011544797.1XP_011543099.1  serine/threonine-protein kinase MARK2 isoform X10

      Conserved Domains (4) summary
      cd12201
      Location:640738
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    7. XM_011544795.1XP_011543097.1  serine/threonine-protein kinase MARK2 isoform X8

      Conserved Domains (4) summary
      cd12201
      Location:646744
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    8. XM_011544791.1XP_011543093.1  serine/threonine-protein kinase MARK2 isoform X3

      Conserved Domains (4) summary
      cd12201
      Location:699797
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    9. XM_011544794.1XP_011543096.1  serine/threonine-protein kinase MARK2 isoform X7

      Conserved Domains (4) summary
      cd12201
      Location:654752
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    10. XM_017017311.1XP_016872800.1  serine/threonine-protein kinase MARK2 isoform X11

    11. XM_011544796.1XP_011543098.1  serine/threonine-protein kinase MARK2 isoform X9

      Conserved Domains (4) summary
      cd12201
      Location:645743
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    12. XM_011544798.1XP_011543100.1  serine/threonine-protein kinase MARK2 isoform X12

      Conserved Domains (4) summary
      cd12201
      Location:630728
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:73324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:342383
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:72324
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RNA

    1. XR_949802.2 RNA Sequence

    2. XR_002957128.1 RNA Sequence

    3. XR_949801.2 RNA Sequence

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