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    ELAVL2 ELAV like RNA binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 1993, updated on 8-Jul-2021

    Summary

    Official Symbol
    ELAVL2provided by HGNC
    Official Full Name
    ELAV like RNA binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:3313
    See related
    Ensembl:ENSG00000107105 MIM:601673
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HUB; HELN1; HEL-N1
    Summary
    In humans, the ELAV like RNA binding protein gene family has four members (ELAVL1-4). ELAVL RNA binding proteins recognize AU-rich elements in the 3' UTRs of gene transcripts and thereby regulate gene expression post-transcriptionally. The protein encoded by this gene binds to several 3' UTRs, including its own and also that of FOS, ID, and POU5F1. This gene encodes ELAVL2 and, like ELAVL3 and ELAVL4, is expressed specifically in neurons and primarily localizes to the cytoplasm. This protein also forms a cytosolic complex with the normally nuclear-localized ELAVL1 protein. Alternative splicing of this gene results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Jul 2020]
    Expression
    Biased expression in testis (RPKM 13.9) and brain (RPKM 8.2) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ELAVL2 in Genome Data Viewer
    Location:
    9p21.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (23690099..23850601, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (23690102..23850599, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929563 Neighboring gene SUMO2 pseudogene 2 Neighboring gene NOP56 ribonucleoprotein pseudogene 2 Neighboring gene uncharacterized LOC105375992 Neighboring gene uncharacterized LOC105375993 Neighboring gene zinc finger protein 791 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2018-11-28)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2018-11-28)

    ClinGen Genome Curation PagePubMed

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ELAV-like protein 2
    Names
    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
    ELAV like neuron-specific RNA binding protein 2
    hu-antigen B
    nervous system-specific RNA-binding protein Hel-N1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016425.2 RefSeqGene

      Range
      29335..165537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001171195.2NP_001164666.1  ELAV-like protein 2 isoform b

      See identical proteins and their annotated locations for NP_001164666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS55298.1
      UniProtKB/Swiss-Prot
      Q12926
      Conserved Domains (1) summary
      TIGR01661
      Location:36345
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    2. NM_001171197.2NP_001164668.1  ELAV-like protein 2 isoform b

      See identical proteins and their annotated locations for NP_001164668.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS55298.1
      UniProtKB/Swiss-Prot
      Q12926
      Related
      ENSP00000223951.5, ENST00000223951.10
      Conserved Domains (1) summary
      TIGR01661
      Location:36345
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    3. NM_001351455.2NP_001338384.1  ELAV-like protein 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS87645.1
      Conserved Domains (1) summary
      TIGR01661
      Location:65388
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    4. NM_001351456.2NP_001338385.1  ELAV-like protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:65387
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    5. NM_001351457.2NP_001338386.1  ELAV-like protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:65387
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    6. NM_001351458.2NP_001338387.1  ELAV-like protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:65387
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    7. NM_001351459.2NP_001338388.1  ELAV-like protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:65387
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    8. NM_001351460.2NP_001338389.1  ELAV-like protein 2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:64387
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    9. NM_001351461.2NP_001338390.1  ELAV-like protein 2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:64387
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    10. NM_001351462.2NP_001338391.1  ELAV-like protein 2 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:64386
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    11. NM_001351463.2NP_001338392.1  ELAV-like protein 2 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:64386
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    12. NM_001351464.2NP_001338393.1  ELAV-like protein 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:65374
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    13. NM_001351465.2NP_001338394.1  ELAV-like protein 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:65374
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    14. NM_001351466.2NP_001338395.1  ELAV-like protein 2 isoform h

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:50372
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    15. NM_001351467.2NP_001338396.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:36359
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    16. NM_001351468.2NP_001338397.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:36359
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    17. NM_001351469.2NP_001338398.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:36359
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    18. NM_001351470.2NP_001338399.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:36359
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    19. NM_001351471.2NP_001338400.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:36359
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    20. NM_001351472.2NP_001338401.1  ELAV-like protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS6515.1
      Related
      ENSP00000369460.1, ENST00000380117.5
      Conserved Domains (1) summary
      TIGR01661
      Location:36358
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    21. NM_001351473.2NP_001338402.1  ELAV-like protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS6515.1
      Conserved Domains (1) summary
      TIGR01661
      Location:36358
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    22. NM_001351474.2NP_001338403.1  ELAV-like protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS6515.1
      Conserved Domains (1) summary
      TIGR01661
      Location:36358
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    23. NM_001351475.2NP_001338404.1  ELAV-like protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS6515.1
      Related
      ENSP00000440998.1, ENST00000544538.5
      Conserved Domains (1) summary
      TIGR01661
      Location:36358
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    24. NM_001351476.2NP_001338405.1  ELAV-like protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS6515.1
      Conserved Domains (1) summary
      TIGR01661
      Location:36358
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    25. NM_001351477.2NP_001338406.1  ELAV-like protein 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS55298.1
      Conserved Domains (1) summary
      TIGR01661
      Location:36345
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    26. NM_001351478.2NP_001338407.1  ELAV-like protein 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS55298.1
      Conserved Domains (1) summary
      TIGR01661
      Location:36345
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    27. NM_001385693.1NP_001372622.1  ELAV-like protein 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This variant (27) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:36345
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    28. NM_001385694.1NP_001372623.1  ELAV-like protein 2 isoform j

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:50360
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    29. NM_001385695.1NP_001372624.1  ELAV-like protein 2 isoform k

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:65375
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    30. NM_001385696.1NP_001372625.1  ELAV-like protein 2 isoform m

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:50373
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    31. NM_001385697.1NP_001372626.1  ELAV-like protein 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:65388
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    32. NM_001385698.1NP_001372627.1  ELAV-like protein 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:65388
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    33. NM_001385699.1NP_001372628.1  ELAV-like protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:65387
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    34. NM_001385700.1NP_001372629.1  ELAV-like protein 2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:64387
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    35. NM_001385701.1NP_001372630.1  ELAV-like protein 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:65374
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    36. NM_001385702.1NP_001372631.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:36359
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    37. NM_001385703.1NP_001372632.1  ELAV-like protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:36358
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    38. NM_001385704.1NP_001372633.1  ELAV-like protein 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Related
      ENSP00000369453.4, ENST00000380110.8
      Conserved Domains (1) summary
      TIGR01661
      Location:65388
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    39. NM_001385705.1NP_001372634.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:36359
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    40. NM_001385707.1NP_001372636.1  ELAV-like protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Conserved Domains (1) summary
      TIGR01661
      Location:65387
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    41. NM_004432.5NP_004423.2  ELAV-like protein 2 isoform a

      See identical proteins and their annotated locations for NP_004423.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (a). Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS6515.1
      UniProtKB/Swiss-Prot
      Q12926
      Related
      ENSP00000380479.2, ENST00000397312.7
      Conserved Domains (1) summary
      TIGR01661
      Location:36358
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      23690099..23850601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517779.3XP_011516081.1  ELAV-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011516081.1

      UniProtKB/TrEMBL
      A0A0A0MRX1
      Conserved Domains (1) summary
      TIGR01661
      Location:65388
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    2. XM_011517778.2XP_011516080.2  ELAV-like protein 2 isoform X2

    3. XM_017014415.1XP_016869904.1  ELAV-like protein 2 isoform X4

    4. XM_011517780.3XP_011516082.1  ELAV-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011516082.1

      UniProtKB/TrEMBL
      A0A0A0MRX1
      Conserved Domains (1) summary
      TIGR01661
      Location:65388
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    5. XM_011517786.2XP_011516088.1  ELAV-like protein 2 isoform X6

      See identical proteins and their annotated locations for XP_011516088.1

      Conserved Domains (1) summary
      TIGR01661
      Location:36359
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    6. XM_005251393.3XP_005251450.1  ELAV-like protein 2 isoform X6

      See identical proteins and their annotated locations for XP_005251450.1

      Conserved Domains (1) summary
      TIGR01661
      Location:36359
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    7. XM_024447438.1XP_024303206.1  ELAV-like protein 2 isoform X8

      Conserved Domains (1) summary
      cl25887
      Location:1210
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    8. XM_017014426.1XP_016869915.1  ELAV-like protein 2 isoform X7

      Conserved Domains (1) summary
      TIGR01661
      Location:1224
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    RNA

    1. XR_002956763.1 RNA Sequence

    2. XR_929212.2 RNA Sequence

    3. XR_929211.1 RNA Sequence

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