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    EIF1AX eukaryotic translation initiation factor 1A X-linked [ Homo sapiens (human) ]

    Gene ID: 1964, updated on 12-Aug-2018

    Summary

    Official Symbol
    EIF1AXprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 1A X-linkedprovided by HGNC
    Primary source
    HGNC:HGNC:3250
    See related
    Ensembl:ENSG00000173674 MIM:300186; Vega:OTTHUMG00000022704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF1A; EIF4C; eIF-1A; eIF-4C; EIF1AP1
    Summary
    This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 20.5), endometrium (RPKM 20.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See EIF1AX in Genome Data Viewer
    Location:
    Xp22.12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (20124518..20141848, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (20142636..20159966, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene BCLAF1 and THRAP3 family member 3 Neighboring gene uncharacterized LOC729609 Neighboring gene MAP7 domain containing 2 Neighboring gene microRNA 23c Neighboring gene EIF1AX antisense RNA 1 Neighboring gene small Cajal body-specific RNA 9-like Neighboring gene ribosomal protein S6 kinase A3 Neighboring gene RNA, 7SK small nuclear pseudogene 183

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem (from REACTOME)
      Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystemThe cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF...
    • Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
      Cap-dependent Translation Initiation, organism-specific biosystemTranslation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start c...
    • Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
      Eukaryotic Translation Initiation, organism-specific biosystemInitiation of translation in the majority of eukaryotic cellular mRNAs depends on the 5'-cap (m7GpppN) and involves ribosomal scanning of the 5' untranslated region (5'-UTR) for an initiating AUG sta...
    • Formation of a pool of free 40S subunits, organism-specific biosystem (from REACTOME)
      Formation of a pool of free 40S subunits, organism-specific biosystemThe 80S ribosome dissociates into free 40S (small) and 60S (large) ribosomal subunits. Each ribosomal subunit is constituted by several individual ribosomal proteins and rRNA.
    • Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystem (from REACTOME)
      Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystemBinding of the methionyl-tRNA initiator to the active eIF2:GTP complex results in the formation of the ternary complex. Subsequently, this Met-tRNAi:eIF2:GTP (ternary) complex binds to the complex fo...
    • GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem (from REACTOME)
      GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystemHydrolysis of eIF2-GTP occurs after the Met-tRNAi has recognized the AUG. This reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
      L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemWhile circularization of mRNA during translation initiation is thought to contribute to an increase in the efficiency of translation, it also appears to provide a mechanism for translational silencin...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Ribosomal scanning and start codon recognition, organism-specific biosystem (from REACTOME)
      Ribosomal scanning and start codon recognition, organism-specific biosystemThe 80S ribosome bound to the mRNA moves along the mRNA molecule from its initial site to the initiation codon and forms a 48S complex, in which the initiation codon is base paired to the anticodon o...
    • Translation, organism-specific biosystem (from REACTOME)
      Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
    • Translation initiation complex formation, organism-specific biosystem (from REACTOME)
      Translation initiation complex formation, organism-specific biosystemThe translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. e...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation factor activity, RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    translational initiation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 1A, X-chromosomal
    Names
    Putative eukaryotic translation initiation factor 1A
    eIF-1A X isoform
    eukaryotic translation initiation factor 1A, X chromosome
    eukaryotic translation initiation factor 4C

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412.3NP_001403.1  eukaryotic translation initiation factor 1A, X-chromosomal

      See identical proteins and their annotated locations for NP_001403.1

      Status: REVIEWED

      Source sequence(s)
      AL732366, L18960
      Consensus CDS
      CCDS14196.1
      UniProtKB/Swiss-Prot
      P47813
      Related
      ENSP00000368927.5, OTTHUMP00000024300, ENST00000379607.9, OTTHUMT00000058913
      Conserved Domains (1) summary
      PTZ00329
      Location:1131
      PTZ00329; eukaryotic translation initiation factor 1A; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

      Range
      20124518..20141848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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