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    Pxn paxillin [ Mus musculus (house mouse) ]

    Gene ID: 19303, updated on 4-Jun-2019

    Summary

    Official Symbol
    Pxnprovided by MGI
    Official Full Name
    paxillinprovided by MGI
    Primary source
    MGI:MGI:108295
    See related
    Ensembl:ENSMUSG00000029528
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pax; AW108311; AW123232
    Expression
    Ubiquitous expression in lung adult (RPKM 49.8), colon adult (RPKM 41.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pxn in Genome Data Viewer
    Location:
    5 F; 5 56.1 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (115506676..115555987)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (115956711..116005995)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102639758 Neighboring gene sirtuin 4 Neighboring gene predicted gene, 42007 Neighboring gene predicted gene 13840 Neighboring gene ribosomal protein, large, P0 Neighboring gene GCN1 activator of EIF2AK4 Neighboring gene microRNA 7029

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    BH4 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    neuropilin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    neuropilin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor signaling complex scaffold activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    vinculin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of MAPK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    branching morphogenesis of an epithelial tube IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    lamellipodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to peptide ISO
    Inferred from Sequence Orthology
    more info
     
    substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011223.3NP_035353.1  paxillin isoform alpha

      See identical proteins and their annotated locations for NP_035353.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (alpha) lacks an alternate in-frame exon in the 5' coding region, compared to variant beta. It encodes isoform alpha, which lacks an internal segment and is shorter, compared to isoform beta.
      Source sequence(s)
      AK149933, AW123232, BY198095
      Consensus CDS
      CCDS19593.1
      UniProtKB/Swiss-Prot
      Q8VI36
      Related
      ENSMUSP00000069624.8, ENSMUST00000067268.14
      Conserved Domains (5) summary
      cd09407
      Location:383434
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09409
      Location:442494
      LIM3_Paxillin; The third LIM domain of paxillin
      cd09411
      Location:501552
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:324376
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54253
      Paxillin; Paxillin family
    2. NM_133915.3NP_598676.2  paxillin isoform beta

      See identical proteins and their annotated locations for NP_598676.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (beta) represents the longer transcript and encodes the longer isoform (beta).
      Source sequence(s)
      AC159539, AK149933, AW123232, BY198095
      Consensus CDS
      CCDS39229.1
      UniProtKB/Swiss-Prot
      Q8VI36
      UniProtKB/TrEMBL
      F8VQ28
      Related
      ENSMUSP00000083709.3, ENSMUST00000086523.6
      Conserved Domains (5) summary
      cd09338
      Location:476528
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:417468
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:535586
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:358410
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54253
      Paxillin; Paxillin family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      115506676..115555987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530202.3XP_006530265.1  paxillin isoform X1

      Conserved Domains (5) summary
      cd09338
      Location:9731025
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:914965
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:10321083
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:855907
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54253
      Paxillin; Paxillin family
    2. XM_006530207.3XP_006530270.1  paxillin isoform X3

      Related
      ENSMUSP00000148843.1, ENSMUST00000212819.1
      Conserved Domains (1) summary
      pfam03535
      Location:54253
      Paxillin; Paxillin family
    3. XM_006530205.2XP_006530268.1  paxillin isoform X2

      See identical proteins and their annotated locations for XP_006530268.1

      Conserved Domains (5) summary
      cd09338
      Location:840892
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:781832
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:899950
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:722774
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:1120
      Paxillin; Paxillin family
    4. XM_006530204.2XP_006530267.1  paxillin isoform X2

      See identical proteins and their annotated locations for XP_006530267.1

      Conserved Domains (5) summary
      cd09338
      Location:840892
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:781832
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:899950
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:722774
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:1120
      Paxillin; Paxillin family
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