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    Prps1 phosphoribosyl pyrophosphate synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 19139, updated on 5-Aug-2018

    Summary

    Official Symbol
    Prps1provided by MGI
    Official Full Name
    phosphoribosyl pyrophosphate synthetase 1provided by MGI
    Primary source
    MGI:MGI:97775
    See related
    Ensembl:ENSMUSG00000031432 Vega:OTTMUSG00000018847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PRS-I; C76571; C76678; Prps-1; 2310010D17Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 15.2), CNS E18 (RPKM 14.1) and 27 other tissues See more
    Orthologs

    Genomic context

    See Prps1 in Genome Data Viewer
    Location:
    X F1; X 61.35 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (140456603..140476140)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (136991142..137010679)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 3 Neighboring gene microRNA 3475 Neighboring gene predicted gene, 32113 Neighboring gene predicted gene, 39538 Neighboring gene TSC22 domain family, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    AMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    ribose phosphate diphosphokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribose phosphate diphosphokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    5-phosphoribose 1-diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    5-phosphoribose 1-diphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    AMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    hypoxanthine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    purine nucleobase metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    purine nucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    ribose phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    urate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    ribose phosphate diphosphokinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribose phosphate diphosphokinase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribose-phosphate pyrophosphokinase 1
    Names
    phosphoribosyl pyrophosphate synthase I
    phosphoribosyl pyrophosphate synthetase I
    NP_067438.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021463.4NP_067438.1  ribose-phosphate pyrophosphokinase 1

      See identical proteins and their annotated locations for NP_067438.1

      Status: VALIDATED

      Source sequence(s)
      AK166856, BC054772, BY003422
      Consensus CDS
      CCDS30439.1
      UniProtKB/Swiss-Prot
      Q9D7G0
      Related
      ENSMUSP00000033809.3, OTTMUSP00000020407, ENSMUST00000033809.3, OTTMUST00000045356
      Conserved Domains (1) summary
      COG0462
      Location:1313
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      140456603..140476140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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