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    Srgn serglycin [ Mus musculus (house mouse) ]

    Gene ID: 19073, updated on 14-Oct-2018

    Summary

    Official Symbol
    Srgnprovided by MGI
    Official Full Name
    serglycinprovided by MGI
    Primary source
    MGI:MGI:97756
    See related
    Ensembl:ENSMUSG00000020077 Vega:OTTMUSG00000024719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prg; Sgc; Prg1
    Expression
    Broad expression in placenta adult (RPKM 7.7), spleen adult (RPKM 6.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See Srgn in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (62494427..62529189, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (61957176..61970503, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene suppressor of var1, 3-like 1 (S. cerevisiae) Neighboring gene RIKEN cDNA 4930507D05 gene Neighboring gene VPS26 retromer complex component A Neighboring gene KIF1 binding protein Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mast cell granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic specialization, intracellular component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zymogen granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serglycin
    Names
    gp600
    mastocytoma proteoglycan core protein
    proteoglycan 1, secretory granule
    proteoglycan, secretory granule
    secretory granule proteoglycan core protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358965.1NP_001345894.1  serglycin precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA209819, AK157945, BU754820, CJ073081, CJ276881
      Conserved Domains (1) summary
      pfam04360
      Location:3148
      Serglycin; Serglycin
    2. NM_011157.3NP_035287.1  serglycin precursor

      See identical proteins and their annotated locations for NP_035287.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant, but shorter, transcript. It has a transcriptional start site that is internal relative to that of variant 2. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA209819, AK151357, AK157945, BU754820, CJ276881
      Consensus CDS
      CCDS23889.1
      UniProtKB/Swiss-Prot
      P13609
      Related
      ENSMUSP00000020271.6, ENSMUST00000020271.12
      Conserved Domains (1) summary
      pfam04360
      Location:3148
      Serglycin; Serglycin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      62494427..62529189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513375.2XP_006513438.1  serglycin isoform X2

      UniProtKB/Swiss-Prot
      P13609
      Related
      ENSMUSP00000125622.1, OTTMUSP00000029732, ENSMUST00000160987.7, OTTMUST00000060836
      Conserved Domains (1) summary
      pfam04360
      Location:3148
      Serglycin; Serglycin
    2. XM_006513377.3XP_006513440.1  serglycin isoform X2

      See identical proteins and their annotated locations for XP_006513440.1

      UniProtKB/Swiss-Prot
      P13609
      Conserved Domains (1) summary
      pfam04360
      Location:3148
      Serglycin; Serglycin
    3. XM_006513376.3XP_006513439.1  serglycin isoform X2

      See identical proteins and their annotated locations for XP_006513439.1

      UniProtKB/Swiss-Prot
      P13609
      Conserved Domains (1) summary
      pfam04360
      Location:3148
      Serglycin; Serglycin
    4. XM_006513374.3XP_006513437.1  serglycin isoform X1

      See identical proteins and their annotated locations for XP_006513437.1

      Conserved Domains (1) summary
      pfam04360
      Location:45190
      Serglycin; Serglycin
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