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    Ppard peroxisome proliferator activator receptor delta [ Mus musculus (house mouse) ]

    Gene ID: 19015, updated on 21-Jan-2020

    Summary

    Official Symbol
    Ppardprovided by MGI
    Official Full Name
    peroxisome proliferator activator receptor deltaprovided by MGI
    Primary source
    MGI:MGI:101884
    See related
    Ensembl:ENSMUSG00000002250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NUC1; NUC-1; Nr1c2; Pparb; PPAR[b]; Pparb/d; PPAR-beta; PPARdelta; PPAR-delta
    Expression
    Broad expression in duodenum adult (RPKM 102.2), colon adult (RPKM 88.9) and 16 other tissues See more
    Orthologs

    Genomic context

    See Ppard in Genome Data Viewer
    Location:
    17 A3.3; 17 14.64 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28232754..28301469)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (28369699..28438414)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 523 Neighboring gene differentially expressed in FDCP 6 Neighboring gene RIKEN cDNA 1810013A23 gene Neighboring gene Fanconi anemia, complementation group E Neighboring gene ribosomal protein L10A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II repressing transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    drug binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    linoleic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear receptor transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    prostacyclin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity TAS
    Traceable Author Statement
    more info
    PubMed 
    retinoid X receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anagen IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    axon ensheathment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular process TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to hypoxia IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    embryo implantation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryo implantation TAS
    Traceable Author Statement
    more info
    PubMed 
    epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    fatty acid beta-oxidation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid transport IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    keratinocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cholesterol storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT negative regulation of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of pri-miRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epidermis development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    proteoglycan metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of insulin secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of skeletal muscle satellite cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipid IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vitamin A metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    RNA polymerase II transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peroxisome proliferator-activated receptor delta
    Names
    PPARdelta/beta
    Peroxisome proliferator-activated receptor beta
    nuclear hormone receptor 1
    nuclear receptor subfamily 1 group C member 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011145.3NP_035275.1  peroxisome proliferator-activated receptor delta

      See identical proteins and their annotated locations for NP_035275.1

      Status: VALIDATED

      Source sequence(s)
      AB221579, BC070398, CA978861
      Consensus CDS
      CCDS28575.1
      UniProtKB/Swiss-Prot
      P35396
      UniProtKB/TrEMBL
      Q546I3
      Related
      ENSMUSP00000002320.8, ENSMUST00000002320.15
      Conserved Domains (2) summary
      cd06932
      Location:172439
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:72155
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p6 C57BL/6J

      Range
      28232754..28301469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p6 NOD/ShiLtJ

    Genomic

    1. NT_187005.1 Reference GRCm38.p6 NOD/ShiLtJ

      Range
      922831..991487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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