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    Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 18787, updated on 21-May-2019

    Summary

    Official Symbol
    Serpine1provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade E, member 1provided by MGI
    Primary source
    MGI:MGI:97608
    See related
    Ensembl:ENSMUSG00000037411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAI1; PAI-1; Planh1
    Expression
    Biased expression in placenta adult (RPKM 80.4), liver E18 (RPKM 11.4) and 3 other tissues See more
    Orthologs

    Genomic context

    See Serpine1 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (137061504..137072272, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (137537374..137548142, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene VGF nerve growth factor inducible Neighboring gene adaptor protein complex AP-1, sigma 1 Neighboring gene tripartite motif-containing 56 Neighboring gene mucin 3, intestinal Neighboring gene predicted gene, 40348

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to transforming growth factor beta stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    dentinogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    female gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of plasminogen activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vascular wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of vascular wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelium regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of leukotriene production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of odontoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    replicative senescence ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    chromaffin granule ISO
    Inferred from Sequence Orthology
    more info
     
    collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space HDA PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    plasminogen activator inhibitor 1
    Names
    PAI
    Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)
    endothelial plasminogen activator inhibitor
    nexin, plasminogen activator inhibitor type 1
    plasminogen activator inhibitor, type I
    serine (or cysteine) proteinase inhibitor, clade E, member 1
    serpin E1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008871.2NP_032897.2  plasminogen activator inhibitor 1 precursor

      See identical proteins and their annotated locations for NP_032897.2

      Status: VALIDATED

      Source sequence(s)
      AC147986
      Consensus CDS
      CCDS19761.1
      UniProtKB/TrEMBL
      G5E899
      Related
      ENSMUSP00000039586.4, ENSMUST00000041388.10
      Conserved Domains (1) summary
      cl00137
      Location:29402
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      137061504..137072272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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