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    Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B [ Mus musculus (house mouse) ]

    Gene ID: 18669, updated on 11-Jun-2019

    Summary

    Official Symbol
    Abcb1bprovided by MGI
    Official Full Name
    ATP-binding cassette, sub-family B (MDR/TAP), member 1Bprovided by MGI
    Primary source
    MGI:MGI:97568
    See related
    Ensembl:ENSMUSG00000028970
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mdr; Mdr1; Pgy1; Abcb1; Mdr1b; Pgy-1
    Summary
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene encodes a membrane glycoprotein which confers a multidrug-resistance phenotype. The protein encoded by the human gene is an ATP-dependent drug efflux pump for xenobiotic compounds which is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in adrenal adult (RPKM 39.4), placenta adult (RPKM 7.7) and 4 other tissues See more
    Orthologs

    Genomic context

    See Abcb1b in Genome Data Viewer
    Location:
    5 A1; 5 3.43 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (8798147..8866314)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (8798147..8866314)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RUN domain containing 3B Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 1A Neighboring gene predicted gene, 31157 Neighboring gene predicted gene 5106 Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 4 Neighboring gene calponin 3, acidic pseudogene Neighboring gene predicted gene, 31388

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • ABC transporters, organism-specific biosystem (from KEGG)
      ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
    • ABC transporters, conserved biosystem (from KEGG)
      ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
    • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
      ABC-family proteins mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Bile secretion, organism-specific biosystem (from KEGG)
      Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • Bile secretion, conserved biosystem (from KEGG)
      Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity, coupled to transmembrane movement of substances IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ceramide-translocating ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylcholine-translocating ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylethanolamine-translocating ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    Sertoli cell barrier remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of endothelial blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intercellular canaliculus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    multidrug resistance protein 1B
    Names
    ATP-binding cassette sub-family B member 1
    P glycoprotein 1
    multidrug resistance protein 1
    NP_035205.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011075.2NP_035205.1  multidrug resistance protein 1B

      See identical proteins and their annotated locations for NP_035205.1

      Status: VALIDATED

      Source sequence(s)
      AK030328, AK139854, BG080311, BQ829721, BY435708, DV651684
      Consensus CDS
      CCDS19085.1
      UniProtKB/Swiss-Prot
      P06795
      UniProtKB/TrEMBL
      B2RUR3
      Related
      ENSMUSP00000009058.5, ENSMUST00000009058.9
      Conserved Domains (3) summary
      cd03249
      Location:10331272
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:551270
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:54342
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      8798147..8866314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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