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    Oxt oxytocin [ Mus musculus (house mouse) ]

    Gene ID: 18429, updated on 9-Sep-2018

    Summary

    Official Symbol
    Oxtprovided by MGI
    Official Full Name
    oxytocinprovided by MGI
    Primary source
    MGI:MGI:97453
    See related
    Ensembl:ENSMUSG00000027301 Vega:OTTMUSG00000015519
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OT; Oxy
    Summary
    This gene encodes a preproprotein that is processed to produce oxytocin and neurophysin 1. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin 1. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation, the stress response and complex sexual and maternal behavior, as well as in the regulation of water excretion, salt appetite, blood pressure and cardiovascular functions. Deletion of this gene in mouse reduces bone formation resulting in osteoporosis. [provided by RefSeq, Dec 2013]
    Expression
    Biased expression in CNS E18 (RPKM 1.0), thymus adult (RPKM 0.3) and 5 other tissues See more
    Orthologs

    Genomic context

    See Oxt in Genome Data Viewer
    Location:
    2 F1; 2 63.24 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (130574520..130577054)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (130401909..130402724)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, A Neighboring gene RIKEN cDNA 4930473A02 gene Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene arginine vasopressin Neighboring gene U box domain containing 5 Neighboring gene FAST kinase domains 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    neurohypophyseal hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    neuropeptide hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxytocin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    drinking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    grooming behavior ISO
    Inferred from Sequence Orthology
    more info
     
    maternal behavior ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gastric acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of urine volume ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of female receptivity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hindgut contraction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of penile erection ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of prostaglandin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of uterine smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of digestive system process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    response to progesterone ISO
    Inferred from Sequence Orthology
    more info
     
    sleep ISO
    Inferred from Sequence Orthology
    more info
     
    social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    sperm ejaculation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    oxytocin-neurophysin 1
    Names
    OT-NPI
    neurophysin 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011025.4NP_035155.1  oxytocin-neurophysin 1 preproprotein

      See identical proteins and their annotated locations for NP_035155.1

      Status: REVIEWED

      Source sequence(s)
      AK003042, AL731707, AW455577
      Consensus CDS
      CCDS16745.1
      UniProtKB/Swiss-Prot
      P35454
      UniProtKB/TrEMBL
      Q545V4
      Related
      ENSMUSP00000028764.5, OTTMUSP00000016535, ENSMUST00000028764.5, OTTMUST00000036849
      Conserved Domains (1) summary
      pfam00184
      Location:39116
      Hormone_5; Neurohypophysial hormones, C-terminal Domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      130574520..130577054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498910.3XP_006498973.1  oxytocin-neurophysin 1 isoform X1

      Conserved Domains (1) summary
      pfam00184
      Location:39108
      Hormone_5; Neurohypophysial hormones, C-terminal Domain
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