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    Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) [ Mus musculus (house mouse) ]

    Gene ID: 18293, updated on 2-Oct-2018

    Summary

    Official Symbol
    Ogdhprovided by MGI
    Official Full Name
    oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)provided by MGI
    Primary source
    MGI:MGI:1098267
    See related
    Ensembl:ENSMUSG00000020456 Vega:OTTMUSG00000000782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    d1401; AA409584; mKIAA4192; 2210403E04Rik; 2210412K19Rik
    Expression
    Broad expression in heart adult (RPKM 260.2), kidney adult (RPKM 89.4) and 22 other tissues See more
    Orthologs

    Genomic context

    See Ogdh in Genome Data Viewer
    Location:
    11; 11 A1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (6291597..6359094)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (6191600..6259096)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 Neighboring gene transmembrane p24 trafficking protein 4 Neighboring gene predicted gene, 46270 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene zinc finger, MIZ-type containing 2 Neighboring gene microRNA 7651 Neighboring gene peptidylprolyl isomerase A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4192

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    oxoglutarate dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxoglutarate dehydrogenase (succinyl-transferring) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxoglutarate dehydrogenase (succinyl-transferring) activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiamine pyrophosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    NADH metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cerebellar cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    hippocampus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    histone succinylation ISO
    Inferred from Sequence Orthology
    more info
     
    olfactory bulb mitral cell layer development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    pyramidal neuron development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    striatum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    succinyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    tangential migration from the subventricular zone to the olfactory bulb IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    thalamus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    oxoglutarate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxoglutarate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    2-oxoglutarate dehydrogenase, mitochondrial
    Names
    2-oxoglutarate dehydrogenase complex component E1
    OGDC-E1
    alpha-ketoglutarate dehydrogenase
    oxoglutarate dehydrogenase (lipoamide)
    NP_001239211.1
    NP_001239212.1
    NP_001239216.1
    NP_001239217.1
    NP_035086.2
    XP_006514645.1
    XP_006514646.1
    XP_006514647.1
    XP_006514648.1
    XP_006514649.1
    XP_017169826.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252282.1NP_001239211.1  2-oxoglutarate dehydrogenase, mitochondrial isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK147289, AK169286, AK220536, AL607152
      UniProtKB/Swiss-Prot
      Q60597
      Conserved Domains (5) summary
      PRK09404
      Location:491030
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cd02016
      Location:279542
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      pfam02779
      Location:664879
      Transket_pyr; Transketolase, pyrimidine binding domain
      pfam16078
      Location:4782
      2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
      pfam16870
      Location:8861029
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
    2. NM_001252283.1NP_001239212.1  2-oxoglutarate dehydrogenase, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001239212.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate coding exon, compared to variant 1. The resulting isoform (2) has a shorter and different internal segment, compared to isoform 1. Variants 2, 6 and 7 encode the same isoform (2).
      Source sequence(s)
      AK147289, AL607152, BC057354
      Consensus CDS
      CCDS56758.1
      UniProtKB/Swiss-Prot
      Q60597
      Related
      ENSMUSP00000091041.3, OTTMUSP00000000736, ENSMUST00000093350.9, OTTMUST00000001535
      Conserved Domains (1) summary
      PRK09404
      Location:491026
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    3. NM_001252287.2NP_001239216.1  2-oxoglutarate dehydrogenase, mitochondrial isoform 3 precursor

      See identical proteins and their annotated locations for NP_001239216.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and a region of the coding sequence, compared to variant 1. The resulting isoform (3) has a shorter and different internal segment, compared to isoform 1. Variants 3, 4 and 8 encode the same isoform (3).
      Source sequence(s)
      AK147289, AL607152, BY768178, CJ145669
      Consensus CDS
      CCDS36106.1
      UniProtKB/Swiss-Prot
      Q60597
      Related
      ENSMUSP00000099090.2, OTTMUSP00000000738, ENSMUST00000101554.8
      Conserved Domains (1) summary
      PRK09404
      Location:491015
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    4. NM_001252288.1NP_001239217.1  2-oxoglutarate dehydrogenase, mitochondrial isoform 4

      See identical proteins and their annotated locations for NP_001239217.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR exon and lacks an in-frame coding exon, compared to variant 1. The resulting isoform (4) lacks an internal segment, compared to isoform 1. Variants 5 and 9 encode the same isoform (4).
      Source sequence(s)
      AK147289, AL607152, BC049104, BY782774, BY785860
      Consensus CDS
      CCDS56759.1
      UniProtKB/Swiss-Prot
      Q60597
      UniProtKB/TrEMBL
      Z4YJV4
      Related
      ENSMUSP00000080569.4, OTTMUSP00000000737, ENSMUST00000081894.4, OTTMUST00000001536
      Conserved Domains (1) summary
      PRK09404
      Location:491011
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    5. NM_001361902.1NP_001348831.1  2-oxoglutarate dehydrogenase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK147289, AL607152, BC049104, BC057354, BY125742
      Conserved Domains (1) summary
      PRK09404
      Location:491026
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    6. NM_001361903.1NP_001348832.1  2-oxoglutarate dehydrogenase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK147289, AL607152, BC057354, CJ145669
      Conserved Domains (1) summary
      PRK09404
      Location:491026
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    7. NM_001361904.1NP_001348833.1  2-oxoglutarate dehydrogenase, mitochondrial isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AK147289, AL607152, BY768178, CK620645
      Conserved Domains (1) summary
      PRK09404
      Location:491015
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    8. NM_001361905.1NP_001348834.1  2-oxoglutarate dehydrogenase, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK147289, AL607152, BB842096, BC049104
      Conserved Domains (1) summary
      PRK09404
      Location:491011
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    9. NM_010956.4NP_035086.2  2-oxoglutarate dehydrogenase, mitochondrial isoform 3 precursor

      See identical proteins and their annotated locations for NP_035086.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in a region of the coding sequence, compared to variant 1. The resulting isoform (3) has a shorter and different internal segment, compared to isoform 1. Variants 3 and 4 encode the same isoform 3.
      Source sequence(s)
      AK147289, AL607152
      Consensus CDS
      CCDS36106.1
      UniProtKB/Swiss-Prot
      Q60597
      Related
      ENSMUSP00000003461.8, OTTMUSP00000000735, ENSMUST00000003461.14, OTTMUST00000001534
      Conserved Domains (1) summary
      PRK09404
      Location:491015
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      6291597..6359094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514586.3XP_006514649.1  2-oxoglutarate dehydrogenase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      Z4YJV4
      Conserved Domains (1) summary
      PRK09404
      Location:491011
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    2. XM_006514583.3XP_006514646.1  2-oxoglutarate dehydrogenase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q60597
      Conserved Domains (1) summary
      PRK09404
      Location:491026
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    3. XM_006514585.2XP_006514648.1  2-oxoglutarate dehydrogenase, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q60597
      Conserved Domains (1) summary
      PRK09404
      Location:491015
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    4. XM_006514582.2XP_006514645.1  2-oxoglutarate dehydrogenase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006514645.1

      UniProtKB/Swiss-Prot
      Q60597
      Conserved Domains (1) summary
      PRK09404
      Location:491026
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    5. XM_006514584.3XP_006514647.1  2-oxoglutarate dehydrogenase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006514647.1

      UniProtKB/Swiss-Prot
      Q60597
      Conserved Domains (1) summary
      PRK09404
      Location:491026
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    6. XM_017314337.1XP_017169826.1  2-oxoglutarate dehydrogenase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q60597
      Conserved Domains (1) summary
      PRK09404
      Location:491026
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
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