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    Ncf2 neutrophil cytosolic factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 17970, updated on 14-Oct-2018

    Summary

    Official Symbol
    Ncf2provided by MGI
    Official Full Name
    neutrophil cytosolic factor 2provided by MGI
    Primary source
    MGI:MGI:97284
    See related
    Ensembl:ENSMUSG00000026480 Vega:OTTMUSG00000049696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NOXA2; Ncf-2; p67phox
    Expression
    Biased expression in genital fat pad adult (RPKM 19.6), spleen adult (RPKM 10.2) and 13 other tissues See more
    Orthologs

    Genomic context

    See Ncf2 in Genome Data Viewer
    Location:
    1 G3; 1 65.05 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (152800153..152836990)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (154655020..154684120)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ral guanine nucleotide dissociation stimulator,-like 1 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) Neighboring gene actin related protein 2/3 complex, subunit 5 Neighboring gene Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) Neighboring gene RIKEN cDNA 1700040K01 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rac GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    superoxide-generating NADPH oxidase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to superoxide-generating NADPH oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to superoxide-generating NADPH oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    NADP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    respiratory burst IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    superoxide anion generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    superoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    NADPH oxidase complex IEA
    Inferred from Electronic Annotation
    more info
     
    acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neutrophil cytosol factor 2
    Names
    67 kDa neutrophil oxidase factor
    NADPH oxidase activator 2
    NADPH oxidase subunit (67kDa)
    neutrophil NADPH oxidase factor 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010877.5NP_035007.1  neutrophil cytosol factor 2

      See identical proteins and their annotated locations for NP_035007.1

      Status: VALIDATED

      Source sequence(s)
      AK036379, BC076609, BY097838
      Consensus CDS
      CCDS15367.1
      UniProtKB/Swiss-Prot
      O70145
      Related
      ENSMUSP00000140404.1, OTTMUSP00000068431, ENSMUST00000186568.6, OTTMUST00000126584
      Conserved Domains (6) summary
      cd06406
      Location:350428
      PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
      cd11871
      Location:244297
      SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
      cd12046
      Location:460511
      SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
      sd00006
      Location:632
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:7198
      TPR_1; Tetratricopeptide repeat
      pfam13424
      Location:38102
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      152800153..152836990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529236.3XP_006529299.1  neutrophil cytosol factor 2 isoform X1

      See identical proteins and their annotated locations for XP_006529299.1

      UniProtKB/Swiss-Prot
      O70145
      Conserved Domains (6) summary
      cd06406
      Location:350428
      PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
      cd11871
      Location:244297
      SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
      cd12046
      Location:460511
      SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
      sd00006
      Location:632
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:7198
      TPR_1; Tetratricopeptide repeat
      pfam13424
      Location:38102
      TPR_12; Tetratricopeptide repeat
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