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    Mxi1 MAX interactor 1, dimerization protein [ Mus musculus (house mouse) ]

    Gene ID: 17859, updated on 3-Oct-2018

    Summary

    Official Symbol
    Mxi1provided by MGI
    Official Full Name
    MAX interactor 1, dimerization proteinprovided by MGI
    Primary source
    MGI:MGI:97245
    See related
    Ensembl:ENSMUSG00000025025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mad2; Gm10197; bHLHc11
    Summary
    This gene encodes a protein containing a helix-loop-helix domain characteristic of transcription factors, which allows heterodimerization and sequence-specific DNA binding. The encoded protein is related to a family of Myc/Max/Mad proteins that are involved in the regulation of several cellular processes. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate Myc function. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 8.9), testis adult (RPKM 8.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mxi1 in Genome Data Viewer
    Location:
    19 D2; 19 47.53 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (53310414..53375810)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (53384996..53450300)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700001K23 gene Neighboring gene predicted gene, 36339 Neighboring gene predicted gene, 30541 Neighboring gene survival motor neuron domain containing 1 Neighboring gene myocardial infarction associated transcript 1 Neighboring gene uncharacterized LOC73899

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    blastocyst formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    RNA polymerase II transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008542.3NP_001008542.2  max-interacting protein 1 isoform b

      See identical proteins and their annotated locations for NP_001008542.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also referred to as SRalpha, differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is longer and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC133451, BC064453
      Consensus CDS
      CCDS38022.1
      UniProtKB/TrEMBL
      Q3U3X2, Q6P2L3
      Related
      ENSMUSP00000003870.7, ENSMUST00000003870.13
      Conserved Domains (1) summary
      smart00353
      Location:140192
      HLH; helix loop helix domain
    2. NM_001008543.3NP_001008543.1  max-interacting protein 1 isoform c

      See identical proteins and their annotated locations for NP_001008543.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also referred to as WR, differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by mRNAs and ESTs but the existence of the protein product has not been verified experimentally. Variants 3-6 encode the same protein.
      Source sequence(s)
      AC133451, L38821
      Consensus CDS
      CCDS38023.1
      UniProtKB/Swiss-Prot
      P50540
      Related
      ENSMUSP00000107366.1, ENSMUST00000111737.1
      Conserved Domains (2) summary
      smart00353
      Location:3789
      HLH; helix loop helix domain
      cl25732
      Location:75155
      SMC_N; RecF/RecN/SMC N terminal domain
    3. NM_001360345.1NP_001347274.1  max-interacting protein 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by mRNAs and ESTs but the existence of the protein product has not been verified experimentally. Variants 3-6 encode the same protein.
      Source sequence(s)
      AC133451
      Conserved Domains (2) summary
      smart00353
      Location:3789
      HLH; helix loop helix domain
      cl25732
      Location:75155
      SMC_N; RecF/RecN/SMC N terminal domain
    4. NM_001360346.1NP_001347275.1  max-interacting protein 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by mRNAs and ESTs but the existence of the protein product has not been verified experimentally. Variants 3-6 encode the same protein.
      Source sequence(s)
      AC133451
      Conserved Domains (2) summary
      smart00353
      Location:3789
      HLH; helix loop helix domain
      cl25732
      Location:75155
      SMC_N; RecF/RecN/SMC N terminal domain
    5. NM_001360347.1NP_001347276.1  max-interacting protein 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by mRNAs and ESTs but the existence of the protein product has not been verified experimentally. Variants 3-6 encode the same protein.
      Source sequence(s)
      AC133451
      Conserved Domains (2) summary
      smart00353
      Location:3789
      HLH; helix loop helix domain
      cl25732
      Location:75155
      SMC_N; RecF/RecN/SMC N terminal domain
    6. NM_001360348.1NP_001347277.1  max-interacting protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (d) is longer and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC133451
      Conserved Domains (2) summary
      smart00353
      Location:80132
      HLH; helix loop helix domain
      cl25732
      Location:118198
      SMC_N; RecF/RecN/SMC N terminal domain
    7. NM_010847.4NP_034977.1  max-interacting protein 1 isoform a

      See identical proteins and their annotated locations for NP_034977.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also referred to as SRbeta, encodes the predominant isoform (a).
      Source sequence(s)
      AC133451, AK140465, CJ170779
      Consensus CDS
      CCDS29901.1
      UniProtKB/Swiss-Prot
      P50540
      UniProtKB/TrEMBL
      Q3USD3
      Related
      ENSMUSP00000025998.7, ENSMUST00000025998.13
      Conserved Domains (1) summary
      smart00353
      Location:73125
      HLH; helix loop helix domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      53310414..53375810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526735.3XP_006526798.1  max-interacting protein 1 isoform X2

      Conserved Domains (1) summary
      smart00353
      Location:135182
      HLH; helix loop helix domain
    2. XM_017318079.1XP_017173568.1  max-interacting protein 1 isoform X3

      Conserved Domains (2) summary
      smart00353
      Location:80132
      HLH; helix loop helix domain
      cl25732
      Location:118198
      SMC_N; RecF/RecN/SMC N terminal domain
    3. XM_006526739.1XP_006526802.1  max-interacting protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006526802.1

      UniProtKB/Swiss-Prot
      P50540
      Conserved Domains (2) summary
      smart00353
      Location:3789
      HLH; helix loop helix domain
      cl25732
      Location:75155
      SMC_N; RecF/RecN/SMC N terminal domain
    4. XM_006526740.1XP_006526803.1  max-interacting protein 1 isoform X4

      UniProtKB/Swiss-Prot
      P50540
      Conserved Domains (2) summary
      smart00353
      Location:3789
      HLH; helix loop helix domain
      cl25732
      Location:75155
      SMC_N; RecF/RecN/SMC N terminal domain
    5. XM_006526741.2XP_006526804.2  max-interacting protein 1 isoform X1

    6. XM_006526738.1XP_006526801.1  max-interacting protein 1 isoform X4

      UniProtKB/Swiss-Prot
      P50540
      Conserved Domains (2) summary
      smart00353
      Location:3789
      HLH; helix loop helix domain
      cl25732
      Location:75155
      SMC_N; RecF/RecN/SMC N terminal domain
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