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    Mdh2 malate dehydrogenase 2, NAD (mitochondrial) [ Mus musculus (house mouse) ]

    Gene ID: 17448, updated on 7-Aug-2018

    Summary

    Official Symbol
    Mdh2provided by MGI
    Official Full Name
    malate dehydrogenase 2, NAD (mitochondrial)provided by MGI
    Primary source
    MGI:MGI:97050
    See related
    Ensembl:ENSMUSG00000019179 Vega:OTTMUSG00000022781
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MDH; Mor1; Mdh-2; Mor-1
    Expression
    Broad expression in duodenum adult (RPKM 1627.0), heart adult (RPKM 883.1) and 27 other tissues See more
    Orthologs

    Genomic context

    See Mdh2 in Genome Data Viewer
    Location:
    5 G2; 5 75.4 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (135778649..135790386)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (136254519..136266256)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 120A Neighboring gene microRNA 7034 Neighboring gene serine/threonine/tyrosine interacting-like 1 Neighboring gene uncharacterized LOC105244798 Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene heat shock protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    L-malate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    L-malate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    malate dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    malate dehydrogenase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    malate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    protein self-association ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    NADH metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
     
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    internal protein amino acid acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    malate metabolic process ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    malate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    oxaloacetate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial inner membrane HDA PubMed 
    mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    malate dehydrogenase, mitochondrial
    Names
    mitochondrial malate dehydrogenase 2, NAD
    NP_032643.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008617.2NP_032643.2  malate dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_032643.2

      Status: PROVISIONAL

      Source sequence(s)
      BC023482
      Consensus CDS
      CCDS19746.1
      UniProtKB/Swiss-Prot
      P08249
      Related
      ENSMUSP00000019323.6, OTTMUSP00000026139, ENSMUST00000019323.10, OTTMUST00000054708
      Conserved Domains (2) summary
      TIGR01772
      Location:26335
      MDH_euk_gproteo; malate dehydrogenase, NAD-dependent
      cd01337
      Location:26334
      MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      135778649..135790386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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