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    Mki67 antigen identified by monoclonal antibody Ki 67 [ Mus musculus (house mouse) ]

    Gene ID: 17345, updated on 17-Oct-2018

    Summary

    Official Symbol
    Mki67provided by MGI
    Official Full Name
    antigen identified by monoclonal antibody Ki 67provided by MGI
    Primary source
    MGI:MGI:106035
    See related
    Ensembl:ENSMUSG00000031004 Vega:OTTMUSG00000060275
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ki67; Ki-67; D630048A14Rik
    Expression
    Biased expression in liver E14 (RPKM 21.8), liver E14.5 (RPKM 14.9) and 8 other tissues See more
    Orthologs

    Genomic context

    See Mki67 in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (135689788..135716409, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (142881471..142908062, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, E Neighboring gene microRNA 1962 Neighboring gene RIKEN cDNA 5830432E09 gene Neighboring gene predicted gene, 36431 Neighboring gene RIKEN cDNA 6330420H09 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholangiocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hepatocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    meiotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    proliferation marker protein Ki-67; antigen KI-67
    Names
    antigen KI-67 homolog
    antigen Ki67 homolog
    antigen identified by monoclonal antibody Ki-67 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081117.2NP_001074586.2  proliferation marker protein Ki-67

      Status: PROVISIONAL

      Source sequence(s)
      AC123047, AK052772, AK143677, BC053453
      Consensus CDS
      CCDS52421.1
      UniProtKB/Swiss-Prot
      E9PVX6
      Related
      ENSMUSP00000033310.7, OTTMUSP00000076785, ENSMUST00000033310.8, OTTMUST00000147537
      Conserved Domains (4) summary
      COG1716
      Location:1192
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:7101
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08065
      Location:11091216
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:463529
      PP1_bind; Protein phosphatase 1 binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      135689788..135716409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507413.3XP_006507476.1  antigen KI-67 isoform X3

      Conserved Domains (4) summary
      COG1716
      Location:1192
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:7101
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08065
      Location:789896
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:143209
      PP1_bind; Protein phosphatase 1 binding
    2. XM_006507411.3XP_006507474.1  antigen KI-67 isoform X1

      Conserved Domains (4) summary
      COG1716
      Location:1192
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:7101
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08065
      Location:831938
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:185251
      PP1_bind; Protein phosphatase 1 binding
    3. XM_006507412.3XP_006507475.1  antigen KI-67 isoform X2

      Conserved Domains (2) summary
      pfam08065
      Location:9651072
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:319385
      PP1_bind; Protein phosphatase 1 binding
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