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    Mdfi MyoD family inhibitor [ Mus musculus (house mouse) ]

    Gene ID: 17240, updated on 31-Jan-2019

    Summary

    Official Symbol
    Mdfiprovided by MGI
    Official Full Name
    MyoD family inhibitorprovided by MGI
    Primary source
    MGI:MGI:107687
    See related
    Ensembl:ENSMUSG00000032717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I-mf; I-mfa
    Expression
    Broad expression in limb E14.5 (RPKM 46.3), ovary adult (RPKM 39.9) and 16 other tissues See more
    Orthologs

    Genomic context

    See Mdfi in Genome Data Viewer
    Location:
    17 C; 17 23.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (47815328..47834691, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (47952281..47971640, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene progastricsin (pepsinogen C) Neighboring gene transcription factor EB Neighboring gene forkhead box P4 Neighboring gene predicted gene, 38637 Neighboring gene predicted gene, 46601

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    trophoblast giant cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myoD family inhibitor
    Names
    myogenic repressor I-mf

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109973.2NP_001103443.1  myoD family inhibitor isoform 1

      See identical proteins and their annotated locations for NP_001103443.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AA048074, AA049446, AC113536, AI325040, AV360686, BY097762, CX564914, W65565
      Consensus CDS
      CCDS50134.1
      UniProtKB/Swiss-Prot
      P70331
      Related
      ENSMUSP00000069915.6, ENSMUST00000066368.12
      Conserved Domains (1) summary
      pfam15316
      Location:87246
      MDFI; MyoD family inhibitor
    2. NM_001276390.1NP_001263319.1  myoD family inhibitor isoform 1

      See identical proteins and their annotated locations for NP_001263319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon structure and differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AA049446, AC113536, AI325040, BQ832230, CX564914, W54345, W65565
      Consensus CDS
      CCDS50134.1
      UniProtKB/Swiss-Prot
      P70331
      Conserved Domains (1) summary
      pfam15316
      Location:87246
      MDFI; MyoD family inhibitor
    3. NM_001276391.1NP_001263320.1  myoD family inhibitor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001263320.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' exon structure, differs in the 5' UTR, contains an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 2. It encodes isoform 2 which is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AA049446, AC113536, AI325040, CX564914, W54345, W65565
      Conserved Domains (1) summary
      pfam15316
      Location:92251
      MDFI; MyoD family inhibitor
    4. NM_010783.3NP_034913.2  myoD family inhibitor isoform 1

      See identical proteins and their annotated locations for NP_034913.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate 5' exon structure and differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AA049446, AC113536, AI325040, CX564914, W54345, W65565
      Consensus CDS
      CCDS50134.1
      UniProtKB/Swiss-Prot
      P70331
      Related
      ENSMUSP00000037888.7, ENSMUST00000035375.13
      Conserved Domains (1) summary
      pfam15316
      Location:87246
      MDFI; MyoD family inhibitor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      47815328..47834691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523742.2XP_006523805.2  myoD family inhibitor isoform X1

      See identical proteins and their annotated locations for XP_006523805.2

      Conserved Domains (1) summary
      pfam15316
      Location:92251
      MDFI; MyoD family inhibitor
    2. XM_006523744.3XP_006523807.1  myoD family inhibitor isoform X2

      See identical proteins and their annotated locations for XP_006523807.1

      UniProtKB/Swiss-Prot
      P70331
      Conserved Domains (1) summary
      pfam15316
      Location:87161
      MDFI; MyoD family inhibitor
    3. XM_006523745.3XP_006523808.1  myoD family inhibitor isoform X2

      See identical proteins and their annotated locations for XP_006523808.1

      UniProtKB/Swiss-Prot
      P70331
      Conserved Domains (1) summary
      pfam15316
      Location:87161
      MDFI; MyoD family inhibitor
    4. XM_006523743.3XP_006523806.1  myoD family inhibitor isoform X2

      See identical proteins and their annotated locations for XP_006523806.1

      UniProtKB/Swiss-Prot
      P70331
      Conserved Domains (1) summary
      pfam15316
      Location:87161
      MDFI; MyoD family inhibitor
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