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    Mcpt4 mast cell protease 4 [ Mus musculus (house mouse) ]

    Gene ID: 17227, updated on 12-Aug-2018

    Summary

    Official Symbol
    Mcpt4provided by MGI
    Official Full Name
    mast cell protease 4provided by MGI
    Primary source
    MGI:MGI:96940
    See related
    Ensembl:ENSMUSG00000061068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mcp4; Mcp-4; MMCP-4; MMCP-4A; MMCP-4B
    Expression
    Biased expression in mammary gland adult (RPKM 17.6), bladder adult (RPKM 2.6) and 4 other tissues See more

    Genomic context

    See Mcpt4 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (56059744..56062310, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (56678581..56681147, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene mast cell protease 1 Neighboring gene mast cell protease 2 Neighboring gene mast cell protease 9 Neighboring gene microRNA 6949 Neighboring gene mast cell protease 8 Neighboring gene cathepsin G

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of angiotensin levels in blood IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mast cell protease 4
    Names
    MSMCP
    myonase
    serosal mast cell protease

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010779.2NP_034909.2  mast cell protease 4 precursor

      See identical proteins and their annotated locations for NP_034909.2

      Status: VALIDATED

      Source sequence(s)
      AK144385, AV018388, CJ046459
      Consensus CDS
      CCDS27140.1
      UniProtKB/Swiss-Prot
      P21812
      UniProtKB/TrEMBL
      Q3UN88
      Related
      ENSMUSP00000038103.8, ENSMUST00000043249.9
      Conserved Domains (2) summary
      smart00020
      Location:20239
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:21242
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      56059744..56062310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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