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    Mark3 MAP/microtubule affinity regulating kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 17169, updated on 2-Jun-2019

    Summary

    Official Symbol
    Mark3provided by MGI
    Official Full Name
    MAP/microtubule affinity regulating kinase 3provided by MGI
    Primary source
    MGI:MGI:1341865
    See related
    Ensembl:ENSMUSG00000007411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ETK1; Emk2; ETK-1; MPK10; C-TAK1; 1600015G02Rik; A430080F22Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 28.6), CNS E14 (RPKM 28.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mark3 in Genome Data Viewer
    Location:
    12; 12 F1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (111574478..111656227)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (112812721..112894438)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 28 Neighboring gene eukaryotic translation initiation factor 5 Neighboring gene RIKEN cDNA 2810029C07 gene Neighboring gene creatine kinase, brain Neighboring gene tRNA methyltransferase 61A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4230

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    tau-protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tau-protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    MAP/microtubule affinity-regulating kinase 3
    Names
    ELKL motif kinase 2
    EMK-2
    EMK2/MARK3 serine-threonine protein kinase
    MPK-10
    NP_067491.2
    NP_073712.2
    XP_006515574.1
    XP_006515575.1
    XP_006515576.1
    XP_006515577.1
    XP_006515578.1
    XP_006515580.1
    XP_006515581.1
    XP_006515582.1
    XP_006515585.1
    XP_011242308.1
    XP_011242309.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370744.1NP_001357673.1  MAP/microtubule affinity-regulating kinase 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC160972, AC163357
    2. NM_001370745.1NP_001357674.1  MAP/microtubule affinity-regulating kinase 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC160972, AC163357
    3. NM_021516.4NP_067491.2  MAP/microtubule affinity-regulating kinase 3 isoform 1

      See identical proteins and their annotated locations for NP_067491.2

      Status: VALIDATED

      Source sequence(s)
      AK083683, AK132247, AV275316
      Consensus CDS
      CCDS26181.1
      UniProtKB/Swiss-Prot
      Q03141
      Related
      ENSMUSP00000082017.5, ENSMUST00000084953.12
      Conserved Domains (4) summary
      cd12196
      Location:645742
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. NM_022801.4NP_073712.2  MAP/microtubule affinity-regulating kinase 3 isoform 2

      See identical proteins and their annotated locations for NP_073712.2

      Status: VALIDATED

      Source sequence(s)
      AC160972, AI850379, AK083683, BC066071, CA575239, CX566304
      Consensus CDS
      CCDS26182.1
      UniProtKB/Swiss-Prot
      Q03141
      Related
      ENSMUSP00000074757.6, ENSMUST00000075281.7
      Conserved Domains (4) summary
      cd12196
      Location:630727
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      111574478..111656227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515511.3XP_006515574.1  MAP/microtubule affinity-regulating kinase 3 isoform X1

      Conserved Domains (4) summary
      cd12196
      Location:707804
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. XM_006515512.3XP_006515575.1  MAP/microtubule affinity-regulating kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A1Y7VNZ6
      Related
      ENSMUSP00000152727.1, ENSMUST00000221753.1
      Conserved Domains (4) summary
      cd12196
      Location:698795
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. XM_006515514.3XP_006515577.1  MAP/microtubule affinity-regulating kinase 3 isoform X4

      Conserved Domains (4) summary
      cd12196
      Location:683780
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. XM_006515513.3XP_006515576.1  MAP/microtubule affinity-regulating kinase 3 isoform X3

      Conserved Domains (4) summary
      cd12196
      Location:691788
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. XM_006515517.3XP_006515580.1  MAP/microtubule affinity-regulating kinase 3 isoform X6

      Conserved Domains (4) summary
      cd12196
      Location:638735
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    6. XM_006515518.3XP_006515581.1  MAP/microtubule affinity-regulating kinase 3 isoform X7

      Conserved Domains (4) summary
      cd12196
      Location:614711
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    7. XM_006515515.3XP_006515578.1  MAP/microtubule affinity-regulating kinase 3 isoform X5

      UniProtKB/Swiss-Prot
      Q03141
      Related
      ENSMUSP00000152483.1, ENSMUST00000221459.1
      Conserved Domains (4) summary
      cd12196
      Location:654751
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    8. XM_006515522.3XP_006515585.1  MAP/microtubule affinity-regulating kinase 3 isoform X11

      Conserved Domains (3) summary
      smart00220
      Location:56307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    9. XM_006515519.1XP_006515582.1  MAP/microtubule affinity-regulating kinase 3 isoform X8

      Conserved Domains (4) summary
      cd12196
      Location:558655
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:1158
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:176218
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cl21453
      Location:1158
      PKc_like; Protein Kinases, catalytic domain
    10. XM_011244006.1XP_011242308.1  MAP/microtubule affinity-regulating kinase 3 isoform X9

      Conserved Domains (1) summary
      cd12196
      Location:359456
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    11. XM_011244007.1XP_011242309.1  MAP/microtubule affinity-regulating kinase 3 isoform X10

      Conserved Domains (1) summary
      cd12196
      Location:343440
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
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