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    Ccr4 C-C motif chemokine receptor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171054, updated on 2-Oct-2018

    Summary

    Official Symbol
    Ccr4provided by RGD
    Official Full Name
    C-C motif chemokine receptor 4provided by RGD
    Primary source
    RGD:620594
    See related
    Ensembl:ENSRNOG00000010315
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cmkbr4
    Summary
    mouse homolog is a chemokine receptor that binds both macrophage inflammatory protein-1 alpha and RANTES [RGD, Feb 2006]
    Expression
    Biased expression in Thymus (RPKM 33.4), Spleen (RPKM 3.5) and 1 other tissue See more
    Orthologs

    Genomic context

    See Ccr4 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (122530152..122535959, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (121843005..121848545, complement)

    Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene cartilage-associated protein-like Neighboring gene transmembrane protein with metallophosphoesterase domain Neighboring gene galactosidase, beta 1 Neighboring gene tripartite motif containing 71 Neighboring gene 60S ribosomal protein L30-like Neighboring gene CCR4-NOT transcription complex, subunit 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    C-C chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    C-C chemokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    homeostasis of number of cells IEA
    Inferred from Electronic Annotation
    more info
     
    homeostasis of number of cells ISO
    Inferred from Sequence Orthology
    more info
     
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to antibiotic IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    tolerance induction IEA
    Inferred from Electronic Annotation
    more info
     
    tolerance induction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    C-C chemokine receptor type 4
    Names
    C-C chemokine receptor 4
    chemokine (C-C motif) receptor 4
    chemokine (C-C) receptor 4
    NP_598216.2
    XP_006243977.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133532.2NP_598216.2  C-C chemokine receptor type 4

      See identical proteins and their annotated locations for NP_598216.2

      Status: PROVISIONAL

      Source sequence(s)
      AF432872
      UniProtKB/TrEMBL
      Q91ZH4
      Related
      ENSRNOP00000013705.1, ENSRNOT00000013705.3
      Conserved Domains (2) summary
      PHA03087
      Location:4320
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional
      cl21561
      Location:50256
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

      Range
      122530152..122535959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243915.3XP_006243977.1  C-C chemokine receptor type 4 isoform X1

      Conserved Domains (2) summary
      PHA03087
      Location:59375
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional
      cl21561
      Location:105311
      7tm_4; Olfactory receptor

    Alternate Rn_Celera

    Genomic

    1. AC_000076.1 Alternate Rn_Celera

      Range
      113423300..113424382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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