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    Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170905, updated on 2-Oct-2018

    Summary

    Official Symbol
    Lfngprovided by RGD
    Official Full Name
    LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by RGD
    Primary source
    RGD:620587
    See related
    Ensembl:ENSRNOG00000001250
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    glycosyltransferase; involved in the epithelial morphogenesis of teeth [RGD, Feb 2006]
    Expression
    Biased expression in Spleen (RPKM 148.2), Lung (RPKM 128.6) and 9 other tissues See more
    Orthologs

    Genomic context

    See Lfng in Genome Data Viewer
    Location:
    12q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16117767..16126211, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (18113805..18123172, complement)

    Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene IQ motif containing E Neighboring gene tweety family member 3 Neighboring gene galectin-related inter-fiber protein Neighboring gene carbohydrate sulfotransferase 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
    • Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Notch Signaling Pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling pathway, organism-specific biosystem (from KEGG)
      Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling pathway, conserved biosystem (from KEGG)
      Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Other types of O-glycan biosynthesis, organism-specific biosystem (from KEGG)
      Other types of O-glycan biosynthesis, organism-specific biosystemO-linked glycosylation is the attachment of monosaccharides to the hydroxyl groups of amino acids, mostly serine and threonine, and is found in eukaryotes, archaea and bacteria. O-glycans exhibit div...
    • Other types of O-glycan biosynthesis, conserved biosystem (from KEGG)
      Other types of O-glycan biosynthesis, conserved biosystemO-linked glycosylation is the attachment of monosaccharides to the hydroxyl groups of amino acids, mostly serine and threonine, and is found in eukaryotes, archaea and bacteria. O-glycans exhibit div...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    biological_process ND
    No biological Data available
    more info
     
    compartment pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    compartment pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    marginal zone B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    marginal zone B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of Notch signaling pathway involved in somitogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Notch signaling pathway involved in somitogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of meiotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein O-linked fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein O-linked fucosylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein O-linked fucosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of somitogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    somitogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    somitogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    integral component of Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
    Names
    O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    lunatic fringe gene homolog
    NP_596884.1
    XP_017453739.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133393.2NP_596884.1  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe precursor

      See identical proteins and their annotated locations for NP_596884.1

      Status: PROVISIONAL

      Source sequence(s)
      BC070933
      UniProtKB/Swiss-Prot
      Q924T4
      Related
      ENSRNOP00000001682.4, ENSRNOT00000001682.6
      Conserved Domains (1) summary
      pfam02434
      Location:109357
      Fringe; Fringe-like

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

      Range
      16117767..16126211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598250.1XP_017453739.1  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X1

    Alternate Rn_Celera

    Genomic

    1. AC_000080.1 Alternate Rn_Celera

      Range
      15790243..15798262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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