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    Slc40a1 solute carrier family 40 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170840, updated on 5-Aug-2018

    Summary

    Official Symbol
    Slc40a1provided by RGD
    Official Full Name
    solute carrier family 40 member 1provided by RGD
    Primary source
    RGD:620180
    See related
    Ensembl:ENSRNOG00000049995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fpn1; Slc11a3; Slc39a1
    Summary
    human homolog acts as an iron transporter and is mutated in an autosomal dominant form of hemochromatosis [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Spleen (RPKM 1065.6), Liver (RPKM 270.1) and 4 other tissues See more

    Genomic context

    See Slc40a1 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (52819451..52830461, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (52560116..52579079, complement)

    Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene similar to Ctps protein Neighboring gene WD repeat domain 75 Neighboring gene aspartate aminotransferase-like Neighboring gene solute carrier family 40 member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ferrous iron transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    iron channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    endothelium development ISO
    Inferred from Sequence Orthology
    more info
     
    ferrous iron export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    lymphocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organismal iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter in response to iron ISO
    Inferred from Sequence Orthology
    more info
     
    spleen development ISO
    Inferred from Sequence Orthology
    more info
     
    spleen trabecula formation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    solute carrier family 40 member 1
    Names
    CAR1
    cell adhesion regulator
    ferroportin-1
    solute carrier family 39 (iron-regulated transporter), member 1
    solute carrier family 40 (iron-regulated transporter), member 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133315.2NP_579849.2  solute carrier family 40 member 1

      See identical proteins and their annotated locations for NP_579849.2

      Status: VALIDATED

      Source sequence(s)
      AF394785, BI288312, CB808602, CK364414, CV104407, CV796629, DY313693
      UniProtKB/Swiss-Prot
      Q923U9
      UniProtKB/TrEMBL
      G3V6H7
      Related
      ENSRNOP00000064964.1, ENSRNOT00000073557.2
      Conserved Domains (1) summary
      pfam06963
      Location:22530
      FPN1; Ferroportin1 (FPN1)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

      Range
      52819451..52830461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000077.1 Alternate Rn_Celera

      Range
      45700875..45718803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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