Format

Send to:

Choose Destination
    • Showing Current items.

    Ltb lymphotoxin B [ Mus musculus (house mouse) ]

    Gene ID: 16994, updated on 10-Sep-2019

    Summary

    Official Symbol
    Ltbprovided by MGI
    Official Full Name
    lymphotoxin Bprovided by MGI
    Primary source
    MGI:MGI:104796
    See related
    Ensembl:ENSMUSG00000024399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p33; Tnfc; LTbeta; Tnfsf3; Tnlg1c; AI662801
    Expression
    Biased expression in spleen adult (RPKM 307.1), thymus adult (RPKM 119.5) and 1 other tissue See more
    Orthologs

    Genomic context

    See Ltb in Genome Data Viewer
    Location:
    17 B1; 17 18.59 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35194507..35196305)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (35331452..35333250)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene natural cytotoxicity triggering receptor 3, pseudogene Neighboring gene leukocyte specific transcript 1 Neighboring gene microRNA 6973a Neighboring gene tumor necrosis factor Neighboring gene microRNA 6974 Neighboring gene lymphotoxin A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (8)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    lymph node development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-12 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    lymphotoxin-beta
    Names
    LT-beta
    TNF-C
    tumor necrosis factor C
    tumor necrosis factor ligand 1c
    tumor necrosis factor ligand superfamily member 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008518.2NP_032544.1  lymphotoxin-beta

      See identical proteins and their annotated locations for NP_032544.1

      Status: VALIDATED

      Source sequence(s)
      BC064062, CR974444, U16985
      Consensus CDS
      CCDS28690.1
      UniProtKB/Swiss-Prot
      P41155
      UniProtKB/TrEMBL
      A0A0U5JAA2
      Related
      ENSMUSP00000025262.5, ENSMUST00000025262.5
      Conserved Domains (1) summary
      cd00184
      Location:154303
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p6 C57BL/6J

      Range
      35194507..35196305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p6 129X1/SvJ

    Genomic

    1. NT_039662.3 Reference GRCm38.p6 129X1/SvJ

      Range
      1444200..1445998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p6 NOD/MrkTac

    Genomic

    1. NT_187027.1 Reference GRCm38.p6 NOD/MrkTac

      Range
      1512690..1514488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p6 NOD/ShiLtJ

    Genomic

    1. NT_187004.1 Reference GRCm38.p6 NOD/ShiLtJ

      Range
      1512931..1514729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center