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    Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) [ Mus musculus (house mouse) ]

    Gene ID: 16913, updated on 9-Apr-2019

    Summary

    Official Symbol
    Psmb8provided by MGI
    Official Full Name
    proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)provided by MGI
    Primary source
    MGI:MGI:1346527
    See related
    Ensembl:ENSMUSG00000024338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lmp7; Lmp-7
    Expression
    Broad expression in thymus adult (RPKM 141.3), large intestine adult (RPKM 117.3) and 15 other tissues See more
    Orthologs

    Genomic context

    See Psmb8 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (34198195..34201454)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34335140..34338399)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) Neighboring gene transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Neighboring gene transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Neighboring gene histocompatibility 2, O region beta locus

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    antigen processing and presentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasomal ubiquitin-independent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis involved in cellular protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spermatoproteasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proteasome subunit beta type-8
    Names
    MC13 (LMP7)
    large multifunctional protease 7
    low molecular mass protein 7
    macropain subunit C13
    multicatalytic endopeptidase complex subunit C13
    proteasome component C13
    proteasome subunit MC13
    proteasome subunit beta-5i
    proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
    proteosome beta 8 subunit
    NP_034854.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010724.2NP_034854.2  proteasome subunit beta type-8 precursor

      See identical proteins and their annotated locations for NP_034854.2

      Status: VALIDATED

      Source sequence(s)
      AK031801, AK150674, CJ235673
      Consensus CDS
      CCDS50073.1
      UniProtKB/Swiss-Prot
      P28063
      Related
      ENSMUSP00000025196.8, ENSMUST00000025196.8
      Conserved Domains (2) summary
      PTZ00488
      Location:40271
      PTZ00488; Proteasome subunit beta type-5; Provisional
      cd03761
      Location:73260
      proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      34198195..34201454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129X1/SvJ

    Genomic

    1. NT_039662.3 Reference GRCm38.p4 129X1/SvJ

      Range
      447119..450372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187027.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      509969..513173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187004.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      510102..513306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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